[3-(4-chlorophenyl)-1-(3-methoxyphenyl)-4-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl]-(3,3-difluoro-azetidin-1-yl)-methanone

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Chemical Name:[3-(4-chlorophenyl)-1-(3-methoxyphenyl)-4-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl]-(3,3-difluoro-azetidin-1-yl)-methanone
CAS No.:1574110-80-7
Molecular Formula:C₂₃H₁₈ClF₅N₂O₂
Molecular Weight:484.853
Hs Code.:

Synonyms:[3-(4-chlorophenyl)-1-(3-methoxyphenyl)-4-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl]-(3,3-difluoro-azetidin-1-yl)-methanone

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Chemical Property of [3-(4-chlorophenyl)-1-(3-methoxyphenyl)-4-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl]-(3,3-difluoro-azetidin-1-yl)-methanone

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Technology Process of [3-(4-chlorophenyl)-1-(3-methoxyphenyl)-4-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl]-(3,3-difluoro-azetidin-1-yl)-methanone

There total 6 articles about [3-(4-chlorophenyl)-1-(3-methoxyphenyl)-4-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl]-(3,3-difluoro-azetidin-1-yl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1574118-50-5
[3-(4-chlorophenyl)-1-(3-methoxyphenyl)-4-methyl-pyrrol-2-yl]-(3,3-difluoroazetidin-1-yl)methanone

: 2926-29-6
Langlois reagent

: 1574110-80-7
[3-(4-chlorophenyl)-1-(3-methoxyphenyl)-4-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl]-(3,3-difluoro-azetidin-1-yl)-methanone

Guidance literature:: [3-(4-chlorophenyl)-1-(3-methoxyphenyl)-4-methyl-pyrrol-2-yl]-(3,3-difluoroazetidin-1-yl)methanone; Langlois reagent; With tert.-butylhydroperoxide; In water; dimethyl sulfoxide; at 0 ℃;

With tert.-butylhydroperoxide; In dichloromethane; water; dimethyl sulfoxide; at 20 ℃; for 38h;

Reference yield:

: 1574118-47-0
[3-(4-chlorophenyl)-4-methyl-1H-pyrrol-2-yl]-(3,3-difluoroazetidin-1-yl)methanone

: 1574110-80-7
[3-(4-chlorophenyl)-1-(3-methoxyphenyl)-4-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl]-(3,3-difluoro-azetidin-1-yl)-methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N`-dimethylethylenediamine; potassium phosphate; copper(l) iodide; 1-methyl-pyrrolidin-2-one / 3 h / 140 °C / Microwave irradiation

2.1: tert.-butylhydroperoxide / water; dimethyl sulfoxide / 0 °C

2.2: 38 h / 20 °C

With 1-methyl-pyrrolidin-2-one; tert.-butylhydroperoxide; potassium phosphate; copper(l) iodide; N,N`-dimethylethylenediamine; In water; dimethyl sulfoxide;

Reference yield:

: 1574118-35-6
3-(4-chlorophenyl)-4-methyl-1H-pyrrole-2-carboxylic acid

: 1574110-80-7
[3-(4-chlorophenyl)-1-(3-methoxyphenyl)-4-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl]-(3,3-difluoro-azetidin-1-yl)-methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride / dichloromethane / 1 h / Reflux

2.1: N,N`-dimethylethylenediamine; potassium phosphate; copper(l) iodide; 1-methyl-pyrrolidin-2-one / 3 h / 140 °C / Microwave irradiation

3.1: tert.-butylhydroperoxide / water; dimethyl sulfoxide / 0 °C

3.2: 38 h / 20 °C

With 1-methyl-pyrrolidin-2-one; tert.-butylhydroperoxide; potassium phosphate; copper(l) iodide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; N,N`-dimethylethylenediamine; In dichloromethane; water; dimethyl sulfoxide;