N-Benzyl-N-vinylpropionamide

Base Information

• Chemical Name: N-Benzyl-N-vinylpropionamide
• CAS No.: 124982-13-4
• Molecular Formula: C₁₂H₁₅NO
• Molecular Weight: 189.257
• Mol file: 124982-13-4.mol

Synonyms:N-Benzyl-N-vinylpropionamide

Chemical Property of N-Benzyl-N-vinylpropionamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-Benzyl-N-vinylpropionamide

There total 4 articles about N-Benzyl-N-vinylpropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

N-(2-bromo-benzyl)-N-vinyl-propionamide (300661-42-1) → N-Benzyl-N-vinylpropionamide (124982-13-4) + N-propionyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:

With tri-n-butyl-tin hydride; 1,1'-azobis(1-cyanocyclohexanenitrile); In toluene; Heating;

DOI:10.1039/b003790g

Reference yield:

N-(2-bromobenzyl)-2-(phenylthio)ethanamine → N-Benzyl-N-vinylpropionamide (124982-13-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 90 percent / Et₃N / CH₂Cl₂ / 20 °C

2: 93 percent / MCPBA / CH₂Cl₂ / 0 °C

3: 81 percent / NaHCO₃ / xylene / Heating

4: 16 percent / Bu₃SnH; azobis(cyclohexancarbonitrile) / toluene / Heating

With tri-n-butyl-tin hydride; sodium hydrogencarbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; 1,1'-azobis(1-cyanocyclohexanenitrile); In dichloromethane; toluene; xylene; 1: Acylation / 2: Oxidation / 3: Elimination / 4: Cyclization;

DOI:10.1039/b003790g

Reference yield:

N-(2-benzenesulfinyl-ethyl)-N-(2-bromo-benzyl)-propionamide (300661-41-0) → N-Benzyl-N-vinylpropionamide (124982-13-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / NaHCO₃ / xylene / Heating

2: 16 percent / Bu₃SnH; azobis(cyclohexancarbonitrile) / toluene / Heating

With tri-n-butyl-tin hydride; sodium hydrogencarbonate; 1,1'-azobis(1-cyanocyclohexanenitrile); In toluene; xylene; 1: Elimination / 2: Cyclization;

DOI:10.1039/b003790g

upstream raw materials:

N-(2-bromo-benzyl)-N-vinyl-propionamide

N-(2-bromo-benzyl)-N-(2-phenylsulfanyl-ethyl)-propionamide

N-(2-benzenesulfinyl-ethyl)-N-(2-bromo-benzyl)-propionamide