3-((3-((4-chloro-2-((1-(3,4-dimethylphenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)benzyl)thio)propanoic acid

Base Information

Chemical Name:3-((3-((4-chloro-2-((1-(3,4-dimethylphenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)benzyl)thio)propanoic acid
CAS No.:1354721-63-3
Molecular Formula:C₂₉H₂₇ClN₄O₄S
Molecular Weight:563.077
Hs Code.:

Synonyms:3-((3-((4-chloro-2-((1-(3,4-dimethylphenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)benzyl)thio)propanoic acid

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Chemical Property of 3-((3-((4-chloro-2-((1-(3,4-dimethylphenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)benzyl)thio)propanoic acid

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Technology Process of 3-((3-((4-chloro-2-((1-(3,4-dimethylphenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)benzyl)thio)propanoic acid

There total 10 articles about 3-((3-((4-chloro-2-((1-(3,4-dimethylphenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)benzyl)thio)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 1354722-05-6
tert-butyl 3-(3-(4-chloro-2-(1-(3,4-dimethylphenyl)-1H-pyrazol-3-yl-carbamoyl)phenylcarbamoyl)benzylthio)propanoate

: 1354721-63-3
3-((3-((4-chloro-2-((1-(3,4-dimethylphenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)benzyl)thio)propanoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 583-71-1
4-bromo-o-xylene

: 1354721-63-3
3-((3-((4-chloro-2-((1-(3,4-dimethylphenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)benzyl)thio)propanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate; L-proline; copper(l) iodide / dimethyl sulfoxide / 85 °C / Inert atmosphere

2.1: hydrogen / palladium on activated charcoal / ethyl acetate; methanol / 20 °C

3.1: pyridine / dichloromethane / 2 h / 20 °C

4.1: zinc; acetic acid / 1 h / 70 °C

4.2: pH 8

5.1: pyridine / dichloromethane

5.2: 1 h / 20 °C

6.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With pyridine; copper(l) iodide; hydrogen; potassium carbonate; acetic acid; trifluoroacetic acid; L-proline; zinc; palladium on activated charcoal; In methanol; dichloromethane; dimethyl sulfoxide; ethyl acetate;

Reference yield:

: 6515-58-8
3-bromomethylbenzoic acid

: 1354721-63-3
3-((3-((4-chloro-2-((1-(3,4-dimethylphenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)benzyl)thio)propanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: ethanol / 20 °C

1.2: pH 3 - 4

2.1: potassium carbonate / water; methanol / 4 h / 60 °C

2.2: pH 3

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 80 °C

3.2: pH 2 - 3

4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1.5 h / 0 - 20 °C

5.1: pyridine / dichloromethane

5.2: 1 h / 20 °C

6.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With pyridine; oxalyl dichloride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; N,N-dimethyl-formamide; In methanol; ethanol; dichloromethane; water; acetonitrile;