N-acetyl-2'-deoxy-2'-fluoro-3'-O--5'-O-tritylcytidine

Base Information

Chemical Name:N-acetyl-2'-deoxy-2'-fluoro-3'-O--5'-O-tritylcytidine
CAS No.:128496-02-6
Molecular Formula:C₃₇H₃₂FN₃O₆S
Molecular Weight:665.742
Hs Code.:

N-acetyl-2'-deoxy-2'-fluoro-3'-O-<phenoxy(thiocarbonyl)>-5'-O-tritylcytidine

Synonyms:N-acetyl-2'-deoxy-2'-fluoro-3'-O--5'-O-tritylcytidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-acetyl-2'-deoxy-2'-fluoro-3'-O--5'-O-tritylcytidine

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Technology Process of N-acetyl-2'-deoxy-2'-fluoro-3'-O--5'-O-tritylcytidine

There total 3 articles about N-acetyl-2'-deoxy-2'-fluoro-3'-O--5'-O-tritylcytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 128496-01-5
N-acetyl-2'-deoxy-2'-fluoro-5'-O-tritylcytidine

: 1005-56-7
phenylcarbonochloridothioate

: 128496-02-6
N-acetyl-2'-deoxy-2'-fluoro-3'-O--5'-O-tritylcytidine

Guidance literature:: With dmap; In acetonitrile; for 1h; Ambient temperature;
DOI:10.1021/jm00170a015

Reference yield:

: 128495-99-8
1-(3,5-O-dibenzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)cytosine

: 128496-02-6
N-acetyl-2'-deoxy-2'-fluoro-3'-O--5'-O-tritylcytidine

Guidance literature:: Multi-step reaction with 3 steps

1: 38 percent / Et₃N / methanol / 16 h / Ambient temperature

2: 2.) pyridine / 1.) methanol, reflux, 1 h, 2.) 100 deg C, 2.5 h

3: 72 percent / 4-(dimethylaminopyridine) / acetonitrile / 1 h / Ambient temperature

With pyridine; dmap; triethylamine; In methanol; acetonitrile;
DOI:10.1021/jm00170a015

Reference yield:

: 56632-83-8
1-(2-fluoro-2-deoxy-β-D-arabinofuranosyl)cytosine

: 128496-02-6
N-acetyl-2'-deoxy-2'-fluoro-3'-O--5'-O-tritylcytidine

Guidance literature:: Multi-step reaction with 2 steps

1: 2.) pyridine / 1.) methanol, reflux, 1 h, 2.) 100 deg C, 2.5 h

2: 72 percent / 4-(dimethylaminopyridine) / acetonitrile / 1 h / Ambient temperature

With pyridine; dmap; In acetonitrile;
DOI:10.1021/jm00170a015