methyl N-(2-(((S)-1-benzyl-2-oxocyclohexyl)methyl)allyl)-N-methyl-L-leucinate

Base Information

Chemical Name:methyl N-(2-(((S)-1-benzyl-2-oxocyclohexyl)methyl)allyl)-N-methyl-L-leucinate
CAS No.:1596248-16-6
Molecular Formula:C₂₅H₃₇NO₃
Molecular Weight:399.574
Hs Code.:

Synonyms:methyl N-(2-(((S)-1-benzyl-2-oxocyclohexyl)methyl)allyl)-N-methyl-L-leucinate

Suppliers and Price of methyl N-(2-(((S)-1-benzyl-2-oxocyclohexyl)methyl)allyl)-N-methyl-L-leucinate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl N-(2-(((S)-1-benzyl-2-oxocyclohexyl)methyl)allyl)-N-methyl-L-leucinate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl N-(2-(((S)-1-benzyl-2-oxocyclohexyl)methyl)allyl)-N-methyl-L-leucinate

There total 8 articles about methyl N-(2-(((S)-1-benzyl-2-oxocyclohexyl)methyl)allyl)-N-methyl-L-leucinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1596247-92-5
methyl N-(2-(((methoxycarbonyl)oxy)methyl)allyl)-N-methyl-L-leucinate

: 1596247-61-8
2-(trimethylsilyl)ethyl 1-benzyl-2-oxocyclohexane-1-carboxylate

: 1596248-16-6
methyl N-(2-(((S)-1-benzyl-2-oxocyclohexyl)methyl)allyl)-N-methyl-L-leucinate

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (R)-4-(tert-butyl)-2-(2-(diphenylphosphino)phenyl)-4,5-dihydrooxazole; tetrabutylammonium triphenyldifluorosilicate; In tetrahydrofuran; at 25 ℃; Glovebox; Inert atmosphere;
DOI:10.1021/ol500355z

Reference yield:

: 1596247-92-5
methyl N-(2-(((methoxycarbonyl)oxy)methyl)allyl)-N-methyl-L-leucinate

: 1596247-61-8
2-(trimethylsilyl)ethyl 1-benzyl-2-oxocyclohexane-1-carboxylate

: 1596248-14-4
methyl N-(2-(((R)-1-benzyl-2-oxocyclohexyl)methyl)allyl)-N-methyl-L-leucinate

: 1596248-16-6
methyl N-(2-(((S)-1-benzyl-2-oxocyclohexyl)methyl)allyl)-N-methyl-L-leucinate

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrabutylammonium triphenyldifluorosilicate; 2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-1,3-oxazole; In tetrahydrofuran; at 25 ℃; Overall yield = 91 %; Optical yield = 70.94 %de; diastereoselective reaction; Glovebox; Inert atmosphere;
DOI:10.1021/ol500355z

Reference yield:

: 181712-21-0
2-(hydroxymethyl)allyl methyl carbonate

: 1596248-16-6
methyl N-(2-(((S)-1-benzyl-2-oxocyclohexyl)methyl)allyl)-N-methyl-L-leucinate

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine; tetrachloromethane / acetonitrile / 2 h / 23 °C / Inert atmosphere

2: sodium iodide; sodium carbonate; tetrabutylammomium bromide / acetonitrile / 14 h / 82 °C / Inert atmosphere

3: formaldehyd; sodium cyanoborohydride / water / 24 h / 23 °C / Inert atmosphere

4: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrabutylammonium triphenyldifluorosilicate; (R)-4-(tert-butyl)-2-(2-(diphenylphosphino)phenyl)-4,5-dihydrooxazole / tetrahydrofuran / 25 °C / Glovebox; Inert atmosphere

With tetrachloromethane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; formaldehyd; (R)-4-(tert-butyl)-2-(2-(diphenylphosphino)phenyl)-4,5-dihydrooxazole; tetrabutylammomium bromide; sodium cyanoborohydride; sodium carbonate; triphenylphosphine; tetrabutylammonium triphenyldifluorosilicate; sodium iodide; In tetrahydrofuran; water; acetonitrile;
DOI:10.1021/ol500355z