[4-[6-(2(S)-acetoxypropylamino)-2-pyridin-3-yl-pyrimidin-4-yl]-3-(3-acetoxy-5-methylphenyl)-pyrazol-1-yl]acetonitrile

Base Information

Chemical Name:[4-[6-(2(S)-acetoxypropylamino)-2-pyridin-3-yl-pyrimidin-4-yl]-3-(3-acetoxy-5-methylphenyl)-pyrazol-1-yl]acetonitrile
CAS No.:1262110-32-6
Molecular Formula:C₂₈H₂₇N₇O₄
Molecular Weight:525.567
Hs Code.:

Synonyms:[4-[6-(2(S)-acetoxypropylamino)-2-pyridin-3-yl-pyrimidin-4-yl]-3-(3-acetoxy-5-methylphenyl)-pyrazol-1-yl]acetonitrile

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Chemical Property of [4-[6-(2(S)-acetoxypropylamino)-2-pyridin-3-yl-pyrimidin-4-yl]-3-(3-acetoxy-5-methylphenyl)-pyrazol-1-yl]acetonitrile

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Technology Process of [4-[6-(2(S)-acetoxypropylamino)-2-pyridin-3-yl-pyrimidin-4-yl]-3-(3-acetoxy-5-methylphenyl)-pyrazol-1-yl]acetonitrile

There total 9 articles about [4-[6-(2(S)-acetoxypropylamino)-2-pyridin-3-yl-pyrimidin-4-yl]-3-(3-acetoxy-5-methylphenyl)-pyrazol-1-yl]acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1188271-28-4
KIST₃₀₁₀₇₂

: 108-24-7
acetic anhydride

: 1262110-32-6
[4-[6-(2(S)-acetoxypropylamino)-2-pyridin-3-yl-pyrimidin-4-yl]-3-(3-acetoxy-5-methylphenyl)-pyrazol-1-yl]acetonitrile

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 120h; Inert atmosphere;

Reference yield:

: 585-81-9
3-hydroxy-5-methylbenzoic acid

: 1262110-32-6
[4-[6-(2(S)-acetoxypropylamino)-2-pyridin-3-yl-pyrimidin-4-yl]-3-(3-acetoxy-5-methylphenyl)-pyrazol-1-yl]acetonitrile

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / dmap / acetone / 12 h / 65 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 24 h / 20 °C

3.1: tetrahydrofuran / 3 h / Reflux

4.1: 20 h / 90 °C

4.2: 12 h / 20 °C

5.1: potassium carbonate / acetone / 2 h / Reflux

5.2: 2 h / Reflux

6.1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / acetonitrile; water / 3 h / 75 °C / Inert atmosphere

7.1: boron dimethyl-trifluoro sulphide / dichloromethane / 12 h / 20 °C / Inert atmosphere

8.1: triethylamine / dichloromethane / 120 h / 20 °C / Inert atmosphere

With boron dimethyl-trifluoro sulphide; potassium carbonate; triethylamine; lithium hexamethyldisilazane; dmap; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; dichloromethane; water; acetone; acetonitrile; 6.1: Suzuki Coupling;

Reference yield:

: 1188271-29-5
2-(2,6-dichloropyrimidin-4-yl)-1-(3-methoxy-5-methylphenyl)ethanone

: 1262110-32-6
[4-[6-(2(S)-acetoxypropylamino)-2-pyridin-3-yl-pyrimidin-4-yl]-3-(3-acetoxy-5-methylphenyl)-pyrazol-1-yl]acetonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran / 3 h / Reflux

2.1: 20 h / 90 °C

2.2: 12 h / 20 °C

3.1: potassium carbonate / acetone / 2 h / Reflux

3.2: 2 h / Reflux

4.1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / acetonitrile; water / 3 h / 75 °C / Inert atmosphere

5.1: boron dimethyl-trifluoro sulphide / dichloromethane / 12 h / 20 °C / Inert atmosphere

6.1: triethylamine / dichloromethane / 120 h / 20 °C / Inert atmosphere

With boron dimethyl-trifluoro sulphide; potassium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; dichloromethane; water; acetone; acetonitrile; 4.1: Suzuki Coupling;