1-(4-(benzyloxy)-3-methoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:1-(4-(benzyloxy)-3-methoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline
CAS No.:41182-99-4
Molecular Formula:C₂₇H₃₁NO₄
Molecular Weight:433.547
Hs Code.:

Synonyms:1-(4-(benzyloxy)-3-methoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(4-(benzyloxy)-3-methoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

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Technology Process of 1-(4-(benzyloxy)-3-methoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

There total 8 articles about 1-(4-(benzyloxy)-3-methoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1-(4-(benzyloxy)-3-methoxybenzyl)-6,7-dimethoxy-2-methylisoquinolinium iodide

: 41182-99-4
1-(4-(benzyloxy)-3-methoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With sodium tetrahydroborate; In methanol; at 25 ℃; for 0.5h; Inert atmosphere;
DOI:10.1016/j.bmcl.2014.10.083

Reference yield:

: 33693-48-0
4-benzyloxy-3-methoxybenzyl alcohol

: 41182-99-4
1-(4-(benzyloxy)-3-methoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1: thionyl chloride / chloroform / 2 h / 60 °C

2: sodium hydride / mineral oil; N,N-dimethyl-formamide / -10 °C / Inert atmosphere

3: sodium hydroxide / water; ethanol / 2 h / 100 °C

4: N,N-dimethyl-formamide / 3 h / 60 °C / Inert atmosphere

5: sodium tetrahydroborate / methanol / 0.5 h / 25 °C / Inert atmosphere

With sodium tetrahydroborate; thionyl chloride; sodium hydride; sodium hydroxide; In methanol; ethanol; chloroform; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmcl.2014.10.083

Reference yield:

: 33688-50-5
1-(benzyloxy)-4-(chloromethyl)-2-methoxybenzene

: 41182-99-4
1-(4-(benzyloxy)-3-methoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / mineral oil; N,N-dimethyl-formamide / -10 °C / Inert atmosphere

2: sodium hydroxide / water; ethanol / 2 h / 100 °C

3: N,N-dimethyl-formamide / 3 h / 60 °C / Inert atmosphere

4: sodium tetrahydroborate / methanol / 0.5 h / 25 °C / Inert atmosphere

With sodium tetrahydroborate; sodium hydride; sodium hydroxide; In methanol; ethanol; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmcl.2014.10.083