ethyl 3-(3-((4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo(1,2-a)(4,1)benzoxazepin-4-yl)propanoyl)-3-azabicyclo(3.1.0)hexane-1-carboxylate

Base Information

Chemical Name:ethyl 3-(3-((4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo(1,2-a)(4,1)benzoxazepin-4-yl)propanoyl)-3-azabicyclo(3.1.0)hexane-1-carboxylate
CAS No.:937055-22-6
Molecular Formula:C₃₁H₃₃ClN₂O₆
Molecular Weight:565.066
Hs Code.:

Synonyms:ethyl 3-(3-((4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo(1,2-a)(4,1)benzoxazepin-4-yl)propanoyl)-3-azabicyclo(3.1.0)hexane-1-carboxylate

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Chemical Property of ethyl 3-(3-((4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo(1,2-a)(4,1)benzoxazepin-4-yl)propanoyl)-3-azabicyclo(3.1.0)hexane-1-carboxylate

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Technology Process of ethyl 3-(3-((4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo(1,2-a)(4,1)benzoxazepin-4-yl)propanoyl)-3-azabicyclo(3.1.0)hexane-1-carboxylate

There total 11 articles about ethyl 3-(3-((4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo(1,2-a)(4,1)benzoxazepin-4-yl)propanoyl)-3-azabicyclo(3.1.0)hexane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 937054-53-0
3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propionic acid

: 63618-09-7
(R)-3-azabicyclo[3.1.0]hexane-1-carboxylic acid ethyl ester

: 937055-22-6
ethyl 3-(3-((4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo(1,2-a)(4,1)benzoxazepin-4-yl)propanoyl)-3-azabicyclo(3.1.0)hexane-1-carboxylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 12h;

Reference yield:

: 937057-86-8
3-benzyl 1-ethyl 3-azabicyclo(3.1.0)hexane-1,3-dicarboxylate

: 937055-22-6
ethyl 3-(3-((4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo(1,2-a)(4,1)benzoxazepin-4-yl)propanoyl)-3-azabicyclo(3.1.0)hexane-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / ethanol

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; In ethanol; dichloromethane;

Reference yield:

: 152911-43-8
(2-amino-5-chlorophenyl)(2,3-dimethoxyphenyl)methanone

: 937055-22-6
ethyl 3-(3-((4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo(1,2-a)(4,1)benzoxazepin-4-yl)propanoyl)-3-azabicyclo(3.1.0)hexane-1-carboxylate

Guidance literature:: Multi-step reaction with 11 steps

1.1: acetic acid / 0.5 h / Heating / reflux

2.1: trichlorophosphate / 0.17 h / 0 - 20 °C

2.2: 2 h / 50 °C / Heating / reflux

2.3: 0.5 h / Heating / reflux

3.1: toluene / 100 °C

4.1: sodium tetrahydroborate / methanol / 1 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 20 °C

6.1: Resolution of racemate

7.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C

7.2: 3 h / 0 °C

8.1: triethylamine / dichloromethane / 3 h / 0 °C

9.1: dimethyl sulfoxide / 13 h / 50 °C

10.1: sodium hydroxide; water; isopropyl alcohol / 96 h / Heating / reflux

10.2: 0 °C

11.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C

With sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; water; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; isopropyl alcohol; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; toluene;