8-(4-methoxy-benzyloxymethyl)-6,6-dimethyl-1,4-dioxa-spiro[4.5]dec-7-ene

Base Information

Chemical Name:8-(4-methoxy-benzyloxymethyl)-6,6-dimethyl-1,4-dioxa-spiro[4.5]dec-7-ene
CAS No.:812651-99-3
Molecular Formula:C₁₉H₂₆O₄
Molecular Weight:318.413
Hs Code.:

Synonyms:8-(4-methoxy-benzyloxymethyl)-6,6-dimethyl-1,4-dioxa-spiro[4.5]dec-7-ene

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Chemical Property of 8-(4-methoxy-benzyloxymethyl)-6,6-dimethyl-1,4-dioxa-spiro[4.5]dec-7-ene

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Technology Process of 8-(4-methoxy-benzyloxymethyl)-6,6-dimethyl-1,4-dioxa-spiro[4.5]dec-7-ene

There total 5 articles about 8-(4-methoxy-benzyloxymethyl)-6,6-dimethyl-1,4-dioxa-spiro[4.5]dec-7-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 53942-86-2
4-methoxybenzyl alcohol sodium salt

: 812652-35-0
7-chloro-6,6-dimethyl-8-methylene-1,4-dioxa-spiro[4.5]decane

: 812651-99-3
8-(4-methoxy-benzyloxymethyl)-6,6-dimethyl-1,4-dioxa-spiro[4.5]dec-7-ene

Guidance literature:: With tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; N,N-dimethyl-formamide; for 10h;
DOI:10.1016/j.tetlet.2004.09.142

Reference yield:

: 14782-52-6
ethylene glycole monoacetal of 2,2-dimethylcyclohexane-1,3-dione

: 812651-99-3
8-(4-methoxy-benzyloxymethyl)-6,6-dimethyl-1,4-dioxa-spiro[4.5]dec-7-ene

Guidance literature:: Multi-step reaction with 5 steps

1.1: LDA / tetrahydrofuran / 0.25 h / 0 °C

1.2: tetrahydrofuran / 1 h / -78 - 0 °C

2.1: DBU / CH₂Cl₂ / 12 h

3.1: 87 percent / CeCl₃*7H₂O; NaBH₄ / methanol / 0.08 h

4.1: 87 percent / pyridine; SOCl₂ / diethyl ether / 1 h / 0 - 20 °C

5.1: 94 percent / TBAI / tetrahydrofuran; dimethylformamide / 10 h

With pyridine; sodium tetrahydroborate; thionyl chloride; cerium(III) chloride; tetra-(n-butyl)ammonium iodide; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; 3.1: Luche reduction;
DOI:10.1016/j.tetlet.2004.09.142

Reference yield:

: 812651-98-2
6,6-dimethyl-8-methylene-1,4-dioxa-spiro[4.5]decan-7-one

: 812651-99-3
8-(4-methoxy-benzyloxymethyl)-6,6-dimethyl-1,4-dioxa-spiro[4.5]dec-7-ene

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / CeCl₃*7H₂O; NaBH₄ / methanol / 0.08 h

2: 87 percent / pyridine; SOCl₂ / diethyl ether / 1 h / 0 - 20 °C

3: 94 percent / TBAI / tetrahydrofuran; dimethylformamide / 10 h

With pyridine; sodium tetrahydroborate; thionyl chloride; cerium(III) chloride; tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide; 1: Luche reduction;
DOI:10.1016/j.tetlet.2004.09.142