trans-methyl 1-phenyl-4-tert-butylcyclohexanecarboxylate

Base Information

• Chemical Name: trans-methyl 1-phenyl-4-tert-butylcyclohexanecarboxylate
• CAS No.: 52866-65-6
• Molecular Formula: C₁₈H₂₆O₂
• Molecular Weight: 274.403
• Mol file: 52866-65-6.mol

Synonyms:trans-methyl 1-phenyl-4-tert-butylcyclohexanecarboxylate

Chemical Property of trans-methyl 1-phenyl-4-tert-butylcyclohexanecarboxylate

Chemical Property:

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Technology Process of trans-methyl 1-phenyl-4-tert-butylcyclohexanecarboxylate

There total 1 articles about trans-methyl 1-phenyl-4-tert-butylcyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

1-bromo-3-(2-bromoethyl)-4,4-dimethylpentane (758-75-8) + benzeneacetic acid methyl ester (101-41-7) → trans-methyl 1-phenyl-4-tert-butylcyclohexanecarboxylate (52866-65-6) + cis-methyl 1-phenyl-4-tert-butylcyclohexanecarboxylate (52866-66-7)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydride; sodium iodide; In N,N-dimethyl-formamide; at 0 ℃; for 2h;

DOI:10.1021/jo00256a014

upstream raw materials:

1-bromo-3-(2-bromoethyl)-4,4-dimethylpentane

benzeneacetic acid methyl ester