<2S-<2α,3α,4β(R^*)>>-tetrahydro-2-methyl-6-oxo-4-<(1-phenylethyl)amino>-2H-pyran-3-carboxylic acid hydrochloride

Base Information

• Chemical Name: <2S-<2α,3α,4β(R^*)>>-tetrahydro-2-methyl-6-oxo-4-<(1-phenylethyl)amino>-2H-pyran-3-carboxylic acid hydrochloride
• CAS No.: 84935-21-7
• Molecular Formula: C₁₅H₁₉NO₄*ClH
• Molecular Weight: 313.781

Synonyms:<2S-<2α,3α,4β(R^*)>>-tetrahydro-2-methyl-6-oxo-4-<(1-phenylethyl)amino>-2H-pyran-3-carboxylic acid hydrochloride

Chemical Property of <2S-<2α,3α,4β(R^*)>>-tetrahydro-2-methyl-6-oxo-4-<(1-phenylethyl)amino>-2H-pyran-3-carboxylic acid hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of <2S-<2α,3α,4β(R^*)>>-tetrahydro-2-methyl-6-oxo-4-<(1-phenylethyl)amino>-2H-pyran-3-carboxylic acid hydrochloride

There total 4 articles about <2S-<2α,3α,4β(R^*)>>-tetrahydro-2-methyl-6-oxo-4-<(1-phenylethyl)amino>-2H-pyran-3-carboxylic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.5%

<2S-<2α,3α,4β(R*)>>-tetrahydro-2-methyl-6-oxo-4-<(1-phenylethyl)amino>-2H-pyran-3-carboxylic acid methyl ester hydrochloride (81972-25-0) → <2S-<2α,3α,4β(R*)>>-tetrahydro-2-methyl-6-oxo-4-<(1-phenylethyl)amino>-2H-pyran-3-carboxylic acid hydrochloride (84935-21-7)

Guidance literature:

With hydrogenchloride; at 75 - 80 ℃; for 15h;

DOI:10.1021/jo00359a021

Reference yield:

3-oxopentanedioic acid dimethyl ester (1830-54-2) → <2S-<2α,3α,4β(R*)>>-tetrahydro-2-methyl-6-oxo-4-<(1-phenylethyl)amino>-2H-pyran-3-carboxylic acid hydrochloride (84935-21-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) acetic acid / 1.) toluene, 60 deg C, 4 h, 2.) toluene, 25 deg C

2: 57 percent / H₂, 85percent aq. H₃PO₄ / 5percent Pt/C / acetic acid / 20 h / 15 - 20 °C / 51714.8 Torr

3: 93.5 percent / 12N aq. HCl / 15 h / 75 - 80 °C

With hydrogenchloride; phosphoric acid; hydrogen; acetic acid; platinum on activated charcoal; In acetic acid;

DOI:10.1021/jo00359a021

Reference yield:

(R)-1-phenyl-ethyl-amine (3886-69-9) → <2S-<2α,3α,4β(R*)>>-tetrahydro-2-methyl-6-oxo-4-<(1-phenylethyl)amino>-2H-pyran-3-carboxylic acid hydrochloride (84935-21-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) acetic acid / 1.) toluene, 60 deg C, 4 h, 2.) toluene, 25 deg C

2: 57 percent / H₂, 85percent aq. H₃PO₄ / 5percent Pt/C / acetic acid / 20 h / 15 - 20 °C / 51714.8 Torr

3: 93.5 percent / 12N aq. HCl / 15 h / 75 - 80 °C

With hydrogenchloride; phosphoric acid; hydrogen; acetic acid; platinum on activated charcoal; In acetic acid;

DOI:10.1021/jo00359a021

upstream raw materials:

<2S-<2α,3α,4β(R^*)>>-tetrahydro-2-methyl-6-oxo-4-<(1-phenylethyl)amino>-2H-pyran-3-carboxylic acid methyl ester hydrochloride

3-oxopentanedioic acid dimethyl ester

(R)-1-phenyl-ethyl-amine

-2-acetyl-3-<(1-phenylethyl)amino>-2-pentenedioic acid dimethyl ester

Downstream raw materials:

<2S-<2R^*,(R^*),3S^*>>-3-amino-2-(1-hydroxyethyl)pentanedioic acid 5-methyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 84935-21-7 <2S-<2α,3α,4β(R^*)>>-tetrahydro-2-methyl-6-oxo-4-<(1-phenylethyl)amino>-2H-pyran-3-carboxylic acid hydrochloride

Send

Send

Metric Ton KG G Pound L ML

Send

Send