O-2,2'-anhydro-1-(3-azido-3-deoxy-5-O-trityl-β-D-arabinofuranosyl)thymine

Base Information

Chemical Name:O-2,2'-anhydro-1-(3-azido-3-deoxy-5-O-trityl-β-D-arabinofuranosyl)thymine
CAS No.:607351-46-2
Molecular Formula:C₂₉H₂₅N₅O₄
Molecular Weight:507.549
Hs Code.:

Synonyms:O-2,2'-anhydro-1-(3-azido-3-deoxy-5-O-trityl-β-D-arabinofuranosyl)thymine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of O-2,2'-anhydro-1-(3-azido-3-deoxy-5-O-trityl-β-D-arabinofuranosyl)thymine

Chemical Property:

Purity/Quality:

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MSDS Files:: SDS file from LookChem

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Technology Process of O-2,2'-anhydro-1-(3-azido-3-deoxy-5-O-trityl-β-D-arabinofuranosyl)thymine

There total 6 articles about O-2,2'-anhydro-1-(3-azido-3-deoxy-5-O-trityl-β-D-arabinofuranosyl)thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 607351-45-1
1-(3-azido-3-deoxy-5-O-trityl-β-D-ribofuranosyl)thymine

: 607351-46-2
O-2,2'-anhydro-1-(3-azido-3-deoxy-5-O-trityl-β-D-arabinofuranosyl)thymine

Guidance literature:: With dmap; trifluoromethane sulfonyl chloride; In dichloromethane; for 2h;
DOI:10.1002/ejoc.200300177

Reference yield:

: 76-83-5
trityl chloride

: 607351-46-2
O-2,2'-anhydro-1-(3-azido-3-deoxy-5-O-trityl-β-D-arabinofuranosyl)thymine

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / 7 h / 65 °C

1.2: 92.7 percent / pyridine / 48 h / 20 °C

2.1: 81 percent / trifluoromethanesulfonyl chloride; DMAP / CH₂Cl₂ / 2 h

With dmap; trifluoromethane sulfonyl chloride; In pyridine; dichloromethane;
DOI:10.1002/ejoc.200300177

Reference yield:

: 75096-64-9
3-Azido-3-deoxy-1,2-di-O-acetyl-5-O-(4-methylbenzoyl)-β-D-ribofuranose

: 607351-46-2
O-2,2'-anhydro-1-(3-azido-3-deoxy-5-O-trityl-β-D-arabinofuranosyl)thymine

Guidance literature:: Multi-step reaction with 4 steps

1.1: chlorotrimethylsilane; pyridine / various solvent(s) / Heating

1.2: trimethylsilil trifluoromethanesulfonate / 1,2-dichloro-ethane / 5 h

2.1: 1.52 g / NaOCH₃ / methanol / 1 h

3.1: pyridine / 7 h / 65 °C

3.2: 92.7 percent / pyridine / 48 h / 20 °C

4.1: 81 percent / trifluoromethanesulfonyl chloride; DMAP / CH₂Cl₂ / 2 h

With pyridine; dmap; chloro-trimethyl-silane; trifluoromethane sulfonyl chloride; sodium methylate; In pyridine; methanol; dichloromethane;
DOI:10.1002/ejoc.200300177