Technology Process of Bzls-D-Glu(OtBu)-OH
There total 1 articles about Bzls-D-Glu(OtBu)-OH which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
water; sodium hydroxide;
In
1,4-dioxane;
for 24h;
pH=8-9;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C / pH 8 - 9
2.1: hydrogen bromide; acetic acid / 3 h / 20 °C
3.1: N,N-dimethyl-formamide / 0.17 h / Cooling with ice
3.2: 0 - 20 °C
4.1: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / ethanol / 33.5 h / 20 °C / Reflux
5.1: acetic anhydride; acetic acid / 2.5 h / 20 °C
5.2: 78 h / 20 - 40 °C
With
hydroxylamine hydrochloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen bromide; acetic anhydride; acetic acid; N-ethyl-N,N-diisopropylamine;
In
ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm2011996
- Guidance literature:
-
Multi-step reaction with 2 steps
1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C / pH 8 - 9
2: hydrogen bromide; acetic acid / 3 h / 20 °C
With
benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen bromide; acetic acid; N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
DOI:10.1021/jm2011996
