Technology Process of Benzyloxycarbonyl-S-(2,4,6-trimethylbenzyl)cysteinyl-tyrosyl-phenylalanyl-glutaminyl-asparaginyl-S-(2,4,6-trimethylbenzyl)cysteine Methyl Ester
There total 11 articles about Benzyloxycarbonyl-S-(2,4,6-trimethylbenzyl)cysteinyl-tyrosyl-phenylalanyl-glutaminyl-asparaginyl-S-(2,4,6-trimethylbenzyl)cysteine Methyl Ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1)Dicyclohexylcarbodiimide, 1-Hydroxybenztriazole, 1)Triethylamine / 1) DMF, -5 to -10 deg C, 1 h 2) Room temperature, 2 h
2: 99 percent / Hydrazine Hydrate / dimethylformamide / 15 h / Ambient temperature; The product was precipitated with water
3: Butylnitrite, HCl / dimethylformamide; dioxane / 0.33 h / -20 °C
With
hydrogenchloride; n-Butyl nitrite; benzotriazol-1-ol; hydrazine hydrate; triethylamine; dicyclohexyl-carbodiimide;
In
1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1135/cccc19832862
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 99 percent / 1-Hydroxybenzotriazole, N-Ethylpiperidine, N,N'-Dicyclohexylcarbodiimide / dimethylformamide; ethyl acetate / 1)1 h stirring at -5 deg C, 2)12 h at room temperature
2: 95 percent / NaOH / methanol; H2O / 1 h / Ambient temperature
3: 1)Dicyclohexylcarbodiimide, 1-Hydroxybenztriazole, 1)Triethylamine / 1) DMF, -5 to -10 deg C, 1 h 2) Room temperature, 2 h
4: 99 percent / Hydrazine Hydrate / dimethylformamide / 15 h / Ambient temperature; The product was precipitated with water
5: Butylnitrite, HCl / dimethylformamide; dioxane / 0.33 h / -20 °C
With
1-ethyl-piperidine; hydrogenchloride; sodium hydroxide; n-Butyl nitrite; benzotriazol-1-ol; hydrazine hydrate; triethylamine; dicyclohexyl-carbodiimide;
In
1,4-dioxane; methanol; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1135/cccc19832862
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 95 percent / NaOH / methanol; H2O / 1 h / Ambient temperature
2: 1)Dicyclohexylcarbodiimide, 1-Hydroxybenztriazole, 1)Triethylamine / 1) DMF, -5 to -10 deg C, 1 h 2) Room temperature, 2 h
3: 99 percent / Hydrazine Hydrate / dimethylformamide / 15 h / Ambient temperature; The product was precipitated with water
4: Butylnitrite, HCl / dimethylformamide; dioxane / 0.33 h / -20 °C
With
hydrogenchloride; sodium hydroxide; n-Butyl nitrite; benzotriazol-1-ol; hydrazine hydrate; triethylamine; dicyclohexyl-carbodiimide;
In
1,4-dioxane; methanol; water; N,N-dimethyl-formamide;
DOI:10.1135/cccc19832862
