di-tert-butyl ((((3-(3-(tert-butyl)phenyl)-6,7-dimethoxyisoquinolin-1-yl)methyl)amino)methylene)dicarbamate

Base Information

Chemical Name:di-tert-butyl ((((3-(3-(tert-butyl)phenyl)-6,7-dimethoxyisoquinolin-1-yl)methyl)amino)methylene)dicarbamate
CAS No.:1352748-08-3
Molecular Formula:C₃₃H₄₆N₄O₆
Molecular Weight:594.751
Hs Code.:

Synonyms:di-tert-butyl ((((3-(3-(tert-butyl)phenyl)-6,7-dimethoxyisoquinolin-1-yl)methyl)amino)methylene)dicarbamate

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Chemical Property of di-tert-butyl ((((3-(3-(tert-butyl)phenyl)-6,7-dimethoxyisoquinolin-1-yl)methyl)amino)methylene)dicarbamate

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Technology Process of di-tert-butyl ((((3-(3-(tert-butyl)phenyl)-6,7-dimethoxyisoquinolin-1-yl)methyl)amino)methylene)dicarbamate

There total 4 articles about di-tert-butyl ((((3-(3-(tert-butyl)phenyl)-6,7-dimethoxyisoquinolin-1-yl)methyl)amino)methylene)dicarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1352036-42-0
1-(bromomethyl)-3-(3-(t-butyl)phenyl)-6,7-dimethoxyisoquinoline

: 332882-82-3,154476-57-0
1,3-bis(t-butoxycarbonyl)guanidine

: 1352748-08-3
di-tert-butyl ((((3-(3-(tert-butyl)phenyl)-6,7-dimethoxyisoquinolin-1-yl)methyl)amino)methylene)dicarbamate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 12h; Inert atmosphere;

Reference yield:

: 16535-98-1
3-hydroxy-6,7-dimethoxy-1-methylisoquinoline

: 1352748-08-3
di-tert-butyl ((((3-(3-(tert-butyl)phenyl)-6,7-dimethoxyisoquinolin-1-yl)methyl)amino)methylene)dicarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 0.5 h / -78 °C

2: potassium carbonate / palladium diacetate; XPhos / acetonitrile; water / 1 h / 100 °C / Inert atmosphere

3: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 2 h / 85 °C

4: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; triethylamine; palladium diacetate; XPhos; In tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1099740-31-4
6,7-dimethoxy-1-methylisoquinolin-3-yl trifluoromethanesulfonate

: 1352748-08-3
di-tert-butyl ((((3-(3-(tert-butyl)phenyl)-6,7-dimethoxyisoquinolin-1-yl)methyl)amino)methylene)dicarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / palladium diacetate; XPhos / acetonitrile; water / 1 h / 100 °C / Inert atmosphere

2: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 2 h / 85 °C

3: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; palladium diacetate; XPhos; In tetrachloromethane; water; N,N-dimethyl-formamide; acetonitrile;