Cefozopran monohydrochloride

Base Information

Chemical Name:Cefozopran monohydrochloride
CAS No.:113981-44-5
Deprecated CAS:216447-42-6,203311-40-4,142352-46-3,123572-84-9,123572-81-6,125905-00-2,1065213-10-6,733804-85-8
Molecular Formula:C19H18ClN9O5S2
Molecular Weight:551.994
Hs Code.:
UNII:060I5C0GRC
NCI Thesaurus Code:C92168

Synonyms:Cefozopran hydrochloride;Firstcin;Cefozopran (hydrochloride);113981-44-5;CEFOZOPRAN HCL;UNII-060I5C0GRC;060I5C0GRC;Cefozopran monohydrochloride;Cefozopranhydrochloride;SCE-2787 hydrochloride;SCE-2787.HCl;SCHEMBL1229838;SCHEMBL9286286;HY-B0771A;(6R,7R)-7-[[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyiminoacetyl]amino]-3-(imidazo[1,2-b]pyridazin-1-ium-1-ylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;hydrochloride;MFCD00944908;AKOS037648568;CCG-270009;CS-3504;CEFOZOPRAN HYDROCHLORIDE [MART.];CEFOZOPRAN HYDROCHLORIDE [WHO-DD];BS-14644;113981-44-5 (HCl);A803043;(-)-1-(((6R,7R)-7-(2-(5-AMINO-1,2,4-THIADIAZOL-3-YL)GLYOXYLAMIDO)-2-CARBOXY-8-OXO-5-THIA-1-AZABICYCLO(4.2.0)OCT-2-EN-3-YL)METHYL)-1H-IMIDAZO(1,2-B)PYRIDAZIN-4-IUM HYDROXIDE INNER SALT, 7(SUP 2)-(Z)-(O-METHYLOXIME), HYDROCHLORIDE;(6R,7R)-7-[[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyimino-1-oxoethyl]amino]-3-(1-imidazo[1,2-b]pyridazin-4-iumylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride;(6R,7R)-7-[[(2Z)-2-(5-azanyl-1,2,4-thiadiazol-3-yl)-2-methoxyimino-ethanoyl]amino]-3-(imidazo[1,2-b]pyridazin-4-ium-1-ylmethyl)-8-oxidanylidene-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride;Imidazo(1,2-b)pyridazinium, 1-((7-(((5-amino-1,2,4-thiadiazol-3-yl)(methoxyimino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-, chloride, (6R-(6alpha,7beta(Z)))-

Suppliers and Price of Cefozopran monohydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Cefozopranhydrochloride 98+%
100mg
$ 253.00

ChemScene
Cefozopran(hydrochloride)
100mg
$ 319.00

ChemScene
Cefozopran(hydrochloride)
50mg
$ 211.00

Ambeed
Cefozopranhydrochloride 98%
50mg
$ 33.00

Ambeed
Cefozopranhydrochloride 98%
10mg
$ 19.00

Total 72 raw suppliers

Chemical Property of Cefozopran monohydrochloride

Chemical Property:

PSA：234.82000
LogP:-3.24120
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:6
Exact Mass:551.0560847
Heavy Atom Count:36
Complexity:960

Purity/Quality:

99%, ^*data from raw suppliers

Cefozopranhydrochloride 98+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CON=C(C1=NSC(=N1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)C[N+]4=C5C=CC=NN5C=C4)C(=O)[O-].Cl
Isomeric SMILES:CO/N=C(/C1=NSC(=N1)N)\C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C[N+]4=C5C=CC=NN5C=C4)C(=O)[O-].Cl

Technology Process of Cefozopran monohydrochloride

There total 3 articles about Cefozopran monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: cefozopran

: 113981-44-5
(6R,7R)-7-[[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyiminoacetyl]amino]-3-(1H-imidazo[1,2-b]pyridazin-4-ium-1-ylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate monohydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether; di-isopropyl ether; at -20 - -10 ℃; for 3h; Temperature; Solvent; Inert atmosphere;

Reference yield:

: 89604-91-1
(Z)-(5-amino-[1,2,4]thiadiazol-3-yl)methoxyiminothioacetic acid S-benzothiazol-2-yl ester

: 7β-amino-3-[(imidazo[1,2-b]pyridazinium-1-yl)methyl]-3-cephem-4-carboxylate hydrochloride

: 113981-44-5
(6R,7R)-7-[[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyiminoacetyl]amino]-3-(1H-imidazo[1,2-b]pyridazin-4-ium-1-ylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate monohydrochloride

Guidance literature:: (Z)-(5-amino-[1,2,4]thiadiazol-3-yl)methoxyiminothioacetic acid S-benzothiazol-2-yl ester; 7β-amino-3-[(imidazo[1,2-b]pyridazinium-1-yl)methyl]-3-cephem-4-carboxylate hydrochloride; With tributyl-amine; In tetrahydrofuran; water; at 15 - 30 ℃; for 5.33333h; pH=6.8 - 7.2;

With hydrogenchloride; In water; at 10 - 15 ℃; pH=~ 1.4;