4-{8-[(4,4-dimethyl-3,4-dihydro-2H-chromen-6-yl)methyl]-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl}benzoic acid trifluoroacetate

Base Information

Chemical Name:4-{8-[(4,4-dimethyl-3,4-dihydro-2H-chromen-6-yl)methyl]-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl}benzoic acid trifluoroacetate
CAS No.:1350758-51-8
Molecular Formula:C₂HF₃O₂*C₂₆H₃₀N₂O₄
Molecular Weight:548.559
Hs Code.:

Synonyms:4-{8-[(4,4-dimethyl-3,4-dihydro-2H-chromen-6-yl)methyl]-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl}benzoic acid trifluoroacetate

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Chemical Property of 4-{8-[(4,4-dimethyl-3,4-dihydro-2H-chromen-6-yl)methyl]-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl}benzoic acid trifluoroacetate

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Technology Process of 4-{8-[(4,4-dimethyl-3,4-dihydro-2H-chromen-6-yl)methyl]-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl}benzoic acid trifluoroacetate

There total 6 articles about 4-{8-[(4,4-dimethyl-3,4-dihydro-2H-chromen-6-yl)methyl]-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl}benzoic acid trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350762-37-6
C₂₇H₃₂N₂O₄

: 76-05-1
trifluoroacetic acid

: 1350758-51-8
4-{8-[(4,4-dimethyl-3,4-dihydro-2H-chromen-6-yl)methyl]-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl}benzoic acid trifluoroacetate

Guidance literature:: C₂₇H₃₂N₂O₄; With water; potassium hydroxide; In methanol; at 60 ℃; for 2h;

trifluoroacetic acid; In water;

Reference yield:

: 1027915-16-7
6-bromo-4,4-dimethylchroman

: 1350758-51-8
4-{8-[(4,4-dimethyl-3,4-dihydro-2H-chromen-6-yl)methyl]-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl}benzoic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexanes / 0.17 h / -78 °C / Inert atmosphere

1.2: -78 °C

2.1: acetic acid; sodium tris(acetoxy)borohydride / dimethyl sulfoxide / 50 °C

3.1: potassium hydroxide; water / methanol / 2 h / 60 °C

With n-butyllithium; water; sodium tris(acetoxy)borohydride; acetic acid; potassium hydroxide; In tetrahydrofuran; methanol; hexanes; dimethyl sulfoxide;

Reference yield:

: 106-41-2
4-bromo-phenol

: 1350758-51-8
4-{8-[(4,4-dimethyl-3,4-dihydro-2H-chromen-6-yl)methyl]-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl}benzoic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 0.25 h / 130 °C

2.1: aluminum (III) chloride / dichloromethane / 0.5 h / 0 °C

3.1: n-butyllithium / tetrahydrofuran; hexanes / 0.17 h / -78 °C / Inert atmosphere

3.2: -78 °C

4.1: acetic acid; sodium tris(acetoxy)borohydride / dimethyl sulfoxide / 50 °C

5.1: potassium hydroxide; water / methanol / 2 h / 60 °C

With aluminum (III) chloride; n-butyllithium; water; sodium tris(acetoxy)borohydride; caesium carbonate; acetic acid; potassium hydroxide; In tetrahydrofuran; methanol; hexanes; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;