(R)-6,6-difluoro-5-(2-fluoro-5-(tetrahydro-2H-pyran-4-yl)phenyl)-5,7,7-trimethyl-1,4-oxazepan-3-one

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Chemical Name:(R)-6,6-difluoro-5-(2-fluoro-5-(tetrahydro-2H-pyran-4-yl)phenyl)-5,7,7-trimethyl-1,4-oxazepan-3-one
CAS No.:1401241-64-2
Molecular Formula:C₁₉H₂₄F₃NO₃
Molecular Weight:371.4
Hs Code.:

Synonyms:(R)-6,6-difluoro-5-(2-fluoro-5-(tetrahydro-2H-pyran-4-yl)phenyl)-5,7,7-trimethyl-1,4-oxazepan-3-one

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Chemical Property of (R)-6,6-difluoro-5-(2-fluoro-5-(tetrahydro-2H-pyran-4-yl)phenyl)-5,7,7-trimethyl-1,4-oxazepan-3-one

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Technology Process of (R)-6,6-difluoro-5-(2-fluoro-5-(tetrahydro-2H-pyran-4-yl)phenyl)-5,7,7-trimethyl-1,4-oxazepan-3-one

There total 11 articles about (R)-6,6-difluoro-5-(2-fluoro-5-(tetrahydro-2H-pyran-4-yl)phenyl)-5,7,7-trimethyl-1,4-oxazepan-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1401241-55-1
(R)-5-[5-(3,6-Dihydro-2H-pyran-4-yl)-2-fluoro-phenyl]-6,6-difluoro-5,7,7-trimethyl-[1,4]oxazepan-3-one

: 1401241-64-2
(R)-6,6-difluoro-5-(2-fluoro-5-(tetrahydro-2H-pyran-4-yl)phenyl)-5,7,7-trimethyl-1,4-oxazepan-3-one

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethyl acetate; at 20 ℃; for 16h;

Reference yield:

: (R)-N-((1E)-1-(5-bromo-2-fluorophenyl)ethylidene)-2-methylpropane-2-sulfinamide

: 1401241-64-2
(R)-6,6-difluoro-5-(2-fluoro-5-(tetrahydro-2H-pyran-4-yl)phenyl)-5,7,7-trimethyl-1,4-oxazepan-3-one

Guidance literature:: Multi-step reaction with 9 steps

1: zinc / tetrahydrofuran / 5 h / Inert atmosphere; Reflux

2: tetrahydrofuran; 2-methyltetrahydrofuran / 18 h / -78 - 23 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 8 h / 23 - 70 °C / Inert atmosphere

4: sodium periodate / ruthenium trichloride / ethyl acetate; acetonitrile; water / 3 h / 23 °C

5: thionyl chloride / 18 h / 23 °C / Reflux

6: dichloromethane / 0.5 h / 0 - 23 °C

7: trimethylaluminum / toluene / 2 h / 23 °C

8: lithium tert-butoxide; XPhos / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / 1,4-dioxane / 16 h / 110 °C / Microwave

9: hydrogen / palladium 10% on activated carbon / ethyl acetate / 16 h / 20 °C

With sodium periodate; thionyl chloride; hydrogen; trimethylaluminum; lithium tert-butoxide; zinc; XPhos; ruthenium trichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; 2-methyltetrahydrofuran; 1,4-dioxane; dichloromethane; water; ethyl acetate; toluene; acetonitrile; 1: Reformatsky Reaction;

Reference yield:

: 1310349-83-7
(R)-3-(5-bromo-2-fluoro-phenyl)-2,2-difluoro-3-((R)-2-methyl-propane-2-sulfinylamino)-butyric acid ethyl ester

: 1401241-64-2
(R)-6,6-difluoro-5-(2-fluoro-5-(tetrahydro-2H-pyran-4-yl)phenyl)-5,7,7-trimethyl-1,4-oxazepan-3-one

Guidance literature:: Multi-step reaction with 8 steps

1: tetrahydrofuran; 2-methyltetrahydrofuran / 18 h / -78 - 23 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 8 h / 23 - 70 °C / Inert atmosphere

3: sodium periodate / ruthenium trichloride / ethyl acetate; acetonitrile; water / 3 h / 23 °C

4: thionyl chloride / 18 h / 23 °C / Reflux

5: dichloromethane / 0.5 h / 0 - 23 °C

6: trimethylaluminum / toluene / 2 h / 23 °C

7: lithium tert-butoxide; XPhos / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / 1,4-dioxane / 16 h / 110 °C / Microwave

8: hydrogen / palladium 10% on activated carbon / ethyl acetate / 16 h / 20 °C

With sodium periodate; thionyl chloride; hydrogen; trimethylaluminum; lithium tert-butoxide; XPhos; ruthenium trichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; 2-methyltetrahydrofuran; 1,4-dioxane; dichloromethane; water; ethyl acetate; toluene; acetonitrile;