(S)-methyl 2-(((benzyloxy)carbonyl)amino)-5,5-difluoro-6-(((trifluoromethyl)sulfonyl)oxy)hexanoate

Base Information

Chemical Name:(S)-methyl 2-(((benzyloxy)carbonyl)amino)-5,5-difluoro-6-(((trifluoromethyl)sulfonyl)oxy)hexanoate
CAS No.:667464-89-3
Molecular Formula:C₁₆H₁₈F₅NO₇S
Molecular Weight:463.379
Hs Code.:

Synonyms:(S)-methyl 2-(((benzyloxy)carbonyl)amino)-5,5-difluoro-6-(((trifluoromethyl)sulfonyl)oxy)hexanoate

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Chemical Property of (S)-methyl 2-(((benzyloxy)carbonyl)amino)-5,5-difluoro-6-(((trifluoromethyl)sulfonyl)oxy)hexanoate

Chemical Property:

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Technology Process of (S)-methyl 2-(((benzyloxy)carbonyl)amino)-5,5-difluoro-6-(((trifluoromethyl)sulfonyl)oxy)hexanoate

There total 3 articles about (S)-methyl 2-(((benzyloxy)carbonyl)amino)-5,5-difluoro-6-(((trifluoromethyl)sulfonyl)oxy)hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 667464-88-2
methyl 2-[(benzyloxycarbonyl)amino]-5,5-difluoro-7-hydroxyheptanoate

: 667464-89-3
(S)-methyl 2-(((benzyloxy)carbonyl)amino)-5,5-difluoro-6-(((trifluoromethyl)sulfonyl)oxy)hexanoate

Guidance literature:: With dmap; In dichloromethane; for 2h;
DOI:10.1021/jm030348f

Reference yield:

: 75266-40-9
N-benzyloxycarbonyl-L-α-vinylglycine methyl ester

: 667464-89-3
(S)-methyl 2-(((benzyloxy)carbonyl)amino)-5,5-difluoro-6-(((trifluoromethyl)sulfonyl)oxy)hexanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: Cu / dimethylformamide / 24 h

1.2: 32 percent / Zn; AcOH / ethanol / 4 h / 80 °C

2.1: NaBH₄ / methanol / 20 °C

3.1: 89 percent / DMAP / CH₂Cl₂ / 2 h

With dmap; sodium tetrahydroborate; copper; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm030348f

Reference yield:

: 667464-87-1
7-ethyl 1-methyl 2-[(benzyloxycarbonyl)amino]-5,5-difluoroheptanedioate

: 667464-89-3
(S)-methyl 2-(((benzyloxy)carbonyl)amino)-5,5-difluoro-6-(((trifluoromethyl)sulfonyl)oxy)hexanoate

Guidance literature:: Multi-step reaction with 2 steps

1: NaBH₄ / methanol / 20 °C

2: 89 percent / DMAP / CH₂Cl₂ / 2 h

With dmap; sodium tetrahydroborate; In methanol; dichloromethane;
DOI:10.1021/jm030348f