2′,6′-dichloropodophyllotoxin

Base Information

• Chemical Name: 2′,6′-dichloropodophyllotoxin
• CAS No.: 1449601-60-8
• Molecular Formula: C₂₂H₂₀Cl₂O₈
• Molecular Weight: 483.302
• Mol file: 1449601-60-8.mol

Synonyms:2′,6′-dichloropodophyllotoxin

Chemical Property of 2′,6′-dichloropodophyllotoxin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2′,6′-dichloropodophyllotoxin

There total 2 articles about 2′,6′-dichloropodophyllotoxin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

podofilox (518-28-5) → 2′,6′-dichloropodophyllotoxin (1449601-60-8)

Guidance literature:

With N-chloro-succinimide; In N,N-dimethyl-formamide; at 0 - 28 ℃; for 24h;

DOI:10.1021/jf4025079

Reference yield: 79.0%

podofilox (518-28-5) → 2′-chloropodophyllotoxin (1449601-57-3) + 2′,6′-dichloropodophyllotoxin (1449601-60-8)

Guidance literature:

With N-chloro-succinimide; In N,N-dimethyl-formamide; at 0 - 28 ℃; for 24h;

DOI:10.1016/j.bmcl.2013.08.044

Reference yield: 88.0%

2′,6′-dichloropodophyllotoxin (1449601-60-8) + acetic acid (64-19-7,77671-22-8) → C24H22Cl2O9 (1449601-84-6)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 28 ℃;

DOI:10.1021/jf4025079

upstream raw materials:

podofilox

Downstream raw materials:

C₂₄H₂₂Cl₂O₉

C₂₅H₂₄Cl₂O₉

C₂₆H₂₆Cl₂O₉

C₃₀H₃₄Cl₂O₉