3-[2-(tert-Butyl-dimethyl-silanyloxy)-4,5-dimethoxy-phenyl]-butyraldehyde

Base Information

Chemical Name:3-[2-(tert-Butyl-dimethyl-silanyloxy)-4,5-dimethoxy-phenyl]-butyraldehyde
CAS No.:118326-07-1
Molecular Formula:C₁₈H₃₀O₄Si
Molecular Weight:338.519
Hs Code.:

Synonyms:3-[2-(tert-Butyl-dimethyl-silanyloxy)-4,5-dimethoxy-phenyl]-butyraldehyde

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Chemical Property of 3-[2-(tert-Butyl-dimethyl-silanyloxy)-4,5-dimethoxy-phenyl]-butyraldehyde

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Technology Process of 3-[2-(tert-Butyl-dimethyl-silanyloxy)-4,5-dimethoxy-phenyl]-butyraldehyde

There total 6 articles about 3-[2-(tert-Butyl-dimethyl-silanyloxy)-4,5-dimethoxy-phenyl]-butyraldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 118326-06-0
3-[2-(tert-Butyl-dimethyl-silanyloxy)-4,5-dimethoxy-phenyl]-butan-1-ol

: 118326-07-1
3-[2-(tert-Butyl-dimethyl-silanyloxy)-4,5-dimethoxy-phenyl]-butyraldehyde

Guidance literature:: With pyridine; dimethyl sulfoxide; dicyclohexyl-carbodiimide; trifluoroacetic acid; In benzene; for 2.5h; Ambient temperature;
DOI:10.1016/S0040-4039(00)96939-9

Reference yield:

: 2033-89-8
3,4-dimethoxyphenol

: 118326-07-1
3-[2-(tert-Butyl-dimethyl-silanyloxy)-4,5-dimethoxy-phenyl]-butyraldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: K₂CO₃ / acetone / 48 h / Heating

2: 2 h / 200 °C

3: imidazole / dimethylformamide / 18.5 h / Ambient temperature

4: 1.) BH₃*(CH₃)2S, 2.) 30percent H₂O₂/aq. NaOH / 1.) THF, 0 deg C, 30 min, room temp., 2 h; 2.) 0 deg C, 1.5 h

5: 93 percent / DMSO/DCC/pyridine/TFA / benzene / 2.5 h / Ambient temperature

With pyridine; 1H-imidazole; sodium hydroxide; dimethylsulfide borane complex; dihydrogen peroxide; potassium carbonate; dimethyl sulfoxide; dicyclohexyl-carbodiimide; trifluoroacetic acid; In N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1016/S0040-4039(00)96939-9

Reference yield:

: 118326-04-8
4,5-dimethoxy-2-(1-methylallyl)phenol

: 118326-07-1
3-[2-(tert-Butyl-dimethyl-silanyloxy)-4,5-dimethoxy-phenyl]-butyraldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: imidazole / dimethylformamide / 18.5 h / Ambient temperature

2: 1.) BH₃*(CH₃)2S, 2.) 30percent H₂O₂/aq. NaOH / 1.) THF, 0 deg C, 30 min, room temp., 2 h; 2.) 0 deg C, 1.5 h

3: 93 percent / DMSO/DCC/pyridine/TFA / benzene / 2.5 h / Ambient temperature

With pyridine; 1H-imidazole; sodium hydroxide; dimethylsulfide borane complex; dihydrogen peroxide; dimethyl sulfoxide; dicyclohexyl-carbodiimide; trifluoroacetic acid; In N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4039(00)96939-9