(±)-ethyl 2-cyano-5-(hydroxyimino)-3,5-diphenylpentanoate

Base Information

• Chemical Name: (±)-ethyl 2-cyano-5-(hydroxyimino)-3,5-diphenylpentanoate
• CAS No.: 1405679-79-9
• Molecular Formula: C₂₀H₂₀N₂O₃
• Molecular Weight: 336.39
• Mol file: 1405679-79-9.mol

Synonyms:(±)-ethyl 2-cyano-5-(hydroxyimino)-3,5-diphenylpentanoate

Chemical Property of (±)-ethyl 2-cyano-5-(hydroxyimino)-3,5-diphenylpentanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (±)-ethyl 2-cyano-5-(hydroxyimino)-3,5-diphenylpentanoate

There total 3 articles about (±)-ethyl 2-cyano-5-(hydroxyimino)-3,5-diphenylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

3-benzoyl-1-cyano-1-ethoxycarbonyl-2-phenylpropane (109694-24-8) → (±)-ethyl 2-cyano-5-(hydroxyimino)-3,5-diphenylpentanoate (1405679-79-9) + (±)-ethyl (3S,4R)-2-(hydroxyimino)-4,6-diphenyl-1,2,3,4-tetrahydropyridine-3-carboxylate

Guidance literature:

With hydroxylamine hydrochloride; sodium acetate; In ethanol; for 1h; Reflux;

DOI:10.1039/c2ob26423d

Reference yield:

benzalacetophenone (94-41-7) → (±)-ethyl 2-cyano-5-(hydroxyimino)-3,5-diphenylpentanoate (1405679-79-9) + (±)-ethyl (3S,4R)-2-(hydroxyimino)-4,6-diphenyl-1,2,3,4-tetrahydropyridine-3-carboxylate

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / dichloromethane / 15 h / Reflux

2: sodium acetate; hydroxylamine hydrochloride / ethanol / 1 h / Reflux

With hydroxylamine hydrochloride; sodium acetate; potassium carbonate; In ethanol; dichloromethane; 1: |Michael Addition;

DOI:10.1039/c2ob26423d

Reference yield:

ethyl 2-cyanoacetate (105-56-6) → (±)-ethyl 2-cyano-5-(hydroxyimino)-3,5-diphenylpentanoate (1405679-79-9) + (±)-ethyl (3S,4R)-2-(hydroxyimino)-4,6-diphenyl-1,2,3,4-tetrahydropyridine-3-carboxylate

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / dichloromethane / 15 h / Reflux

2: sodium acetate; hydroxylamine hydrochloride / ethanol / 1 h / Reflux

With hydroxylamine hydrochloride; sodium acetate; potassium carbonate; In ethanol; dichloromethane; 1: |Michael Addition;

DOI:10.1039/c2ob26423d

upstream raw materials:

benzalacetophenone

ethyl 2-cyanoacetate

3-benzoyl-1-cyano-1-ethoxycarbonyl-2-phenylpropane

Downstream raw materials:

(±)-ethyl 2-cyano-5-(2,4-dinitrophenoxyimino)-3,5-diphenylpentanoate