3-(3,4-dichlorophenyl)-4',4',6,6-tetramethyl-3,5,6,7-tetrahydro-spiro[benzofuran-2(4H),1'-cyclohexane]-2',4,6'-trione

Base Information

Chemical Name:3-(3,4-dichlorophenyl)-4',4',6,6-tetramethyl-3,5,6,7-tetrahydro-spiro[benzofuran-2(4H),1'-cyclohexane]-2',4,6'-trione
CAS No.:1152293-59-8
Molecular Formula:C₂₃H₂₄Cl₂O₄
Molecular Weight:435.347
Hs Code.:

Synonyms:3-(3,4-dichlorophenyl)-4',4',6,6-tetramethyl-3,5,6,7-tetrahydro-spiro[benzofuran-2(4H),1'-cyclohexane]-2',4,6'-trione

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Chemical Property of 3-(3,4-dichlorophenyl)-4',4',6,6-tetramethyl-3,5,6,7-tetrahydro-spiro[benzofuran-2(4H),1'-cyclohexane]-2',4,6'-trione

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Technology Process of 3-(3,4-dichlorophenyl)-4',4',6,6-tetramethyl-3,5,6,7-tetrahydro-spiro[benzofuran-2(4H),1'-cyclohexane]-2',4,6'-trione

There total 3 articles about 3-(3,4-dichlorophenyl)-4',4',6,6-tetramethyl-3,5,6,7-tetrahydro-spiro[benzofuran-2(4H),1'-cyclohexane]-2',4,6'-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 126-81-8
dimedone

: 6287-38-3
3,4-dichlorobenzaldehyde

: 1152293-59-8
3-(3,4-dichlorophenyl)-4',4',6,6-tetramethyl-3,5,6,7-tetrahydro-spiro[benzofuran-2(4H),1'-cyclohexane]-2',4,6'-trione

Guidance literature:: With sodium bromide; In ethanol; at 20 ℃; Electrochemical reaction; Green chemistry;
DOI:10.1016/j.tet.2013.10.056

Reference yield: 83.0%

: 35024-12-5
(4,4-dimethyl-2,6-dioxo-cyclohexyl)-phenyl-iodonium betaine

: 126-81-8
dimedone

: 6287-38-3
3,4-dichlorobenzaldehyde

: 1152293-59-8
3-(3,4-dichlorophenyl)-4',4',6,6-tetramethyl-3,5,6,7-tetrahydro-spiro[benzofuran-2(4H),1'-cyclohexane]-2',4,6'-trione

Guidance literature:: With potassium hydroxide; In 1,4-dioxane; at 110 ℃; for 0.2h; regioselective reaction; Microwave irradiation;
DOI:10.1002/jhet.1732

Reference yield:

: 126-81-8
dimedone

: 1152293-59-8
3-(3,4-dichlorophenyl)-4',4',6,6-tetramethyl-3,5,6,7-tetrahydro-spiro[benzofuran-2(4H),1'-cyclohexane]-2',4,6'-trione

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / methanol; water / 2 h / 20 °C

2: potassium hydroxide / 1,4-dioxane / 0.2 h / 110 °C / Microwave irradiation

With potassium hydroxide; In 1,4-dioxane; methanol; water;
DOI:10.1002/jhet.1732