(S)-2-(2-Hydroxy-3-nitro-benzoylamino)-pentanedioic acid dihexyl ester

Base Information

• Chemical Name: (S)-2-(2-Hydroxy-3-nitro-benzoylamino)-pentanedioic acid dihexyl ester
• CAS No.: 894354-65-5
• Molecular Formula: C₂₄H₃₆N₂O₈
• Molecular Weight: 480.558
• Mol file: 894354-65-5.mol

Synonyms:(S)-2-(2-Hydroxy-3-nitro-benzoylamino)-pentanedioic acid dihexyl ester

Chemical Property of (S)-2-(2-Hydroxy-3-nitro-benzoylamino)-pentanedioic acid dihexyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of (S)-2-(2-Hydroxy-3-nitro-benzoylamino)-pentanedioic acid dihexyl ester

There total 1 articles about (S)-2-(2-Hydroxy-3-nitro-benzoylamino)-pentanedioic acid dihexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

dihexyl L-glutamate tosylate + 3-nitrosalicylic acid (85-38-1) → (S)-2-(2-Hydroxy-3-nitro-benzoylamino)-pentanedioic acid dihexyl ester (894354-65-5)

Guidance literature:

With pyridine; dicyclohexyl-carbodiimide;

DOI:10.1016/j.bmcl.2006.03.023

Reference yield: 91.0%

(S)-2-(2-Hydroxy-3-nitro-benzoylamino)-pentanedioic acid dihexyl ester (894354-65-5) → (S)-2-(3-Amino-2-hydroxy-benzoylamino)-pentanedioic acid dihexyl ester (894354-66-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1016/j.bmcl.2006.03.023

Reference yield:

(S)-2-(2-Hydroxy-3-nitro-benzoylamino)-pentanedioic acid dihexyl ester (894354-65-5) → (S)-2-(3-Formylamino-2-hydroxy-benzoylamino)-pentanedioic acid dihexyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / H₂ / Pd/C / methanol

2: 67 percent / Ac₂O / CH₂Cl₂

With hydrogen; acetic anhydride; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1016/j.bmcl.2006.03.023

upstream raw materials:

3-nitrosalicylic acid

Downstream raw materials:

(S)-2-(3-Amino-2-hydroxy-benzoylamino)-pentanedioic acid dihexyl ester