[(S)-3-(4-Benzyloxy-phenyl)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propionyl]-phosphonic acid diethyl ester

Base Information

• Chemical Name: [(S)-3-(4-Benzyloxy-phenyl)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propionyl]-phosphonic acid diethyl ester
• CAS No.: 251983-08-1
• Molecular Formula: C₂₈H₂₈NO₇P
• Molecular Weight: 521.507

Synonyms:[(S)-3-(4-Benzyloxy-phenyl)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propionyl]-phosphonic acid diethyl ester

Chemical Property of [(S)-3-(4-Benzyloxy-phenyl)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propionyl]-phosphonic acid diethyl ester

Chemical Property:

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Technology Process of [(S)-3-(4-Benzyloxy-phenyl)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propionyl]-phosphonic acid diethyl ester

There total 1 articles about [(S)-3-(4-Benzyloxy-phenyl)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propionyl]-phosphonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-Nα-phthaloyl-O-benzyltyrosine chloride (88036-14-0) + triethyl phosphite (122-52-1) → [(S)-3-(4-Benzyloxy-phenyl)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propionyl]-phosphonic acid diethyl ester (251983-08-1)

Guidance literature:

In tetrahydrofuran; for 20h;

DOI:10.1016/S0040-4039(99)01573-7

Reference yield: 90.0%

[(S)-3-(4-Benzyloxy-phenyl)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propionyl]-phosphonic acid diethyl ester (251983-08-1) → [(1S,2S)-2-Amino-3-(4-benzyloxy-phenyl)-1-hydroxy-propyl]-phosphonic acid diethyl ester

Guidance literature:

With hydrazine hydrate; In ethanol; at 20 ℃; for 12h;

DOI:10.1016/S0040-4039(99)01573-7

Reference yield:

[(S)-3-(4-Benzyloxy-phenyl)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propionyl]-phosphonic acid diethyl ester (251983-08-1) → [(1S,2S)-3-(4-Benzyloxy-phenyl)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-1-hydroxy-propyl]-phosphonic acid diethyl ester

Guidance literature:

With benzo[1,3,2]dioxaborole; In toluene; at -60 ℃; for 0.5h;

DOI:10.1016/S0040-4039(99)01573-7

upstream raw materials:

(S)-N^α-phthaloyl-O-benzyltyrosine chloride

triethyl phosphite

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