benzhydryl 2-<(4S)-4-(2,6-difluorophenylacetylamino)-3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate

Base Information

• Chemical Name: benzhydryl 2-<(4S)-4-(2,6-difluorophenylacetylamino)-3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate
• CAS No.: 128797-31-9
• Molecular Formula: C₂₉H₂₄F₂N₂O₇
• Molecular Weight: 550.516
• Mol file: 128797-31-9.mol

Synonyms:benzhydryl 2-<(4S)-4-(2,6-difluorophenylacetylamino)-3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate

Chemical Property of benzhydryl 2-<(4S)-4-(2,6-difluorophenylacetylamino)-3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of benzhydryl 2-<(4S)-4-(2,6-difluorophenylacetylamino)-3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate

There total 1 articles about benzhydryl 2-<(4S)-4-(2,6-difluorophenylacetylamino)-3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

benzhydryl 2-<(4S)-4-amino-3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate (106962-17-8,106962-18-9,115441-24-2) + 2,6-difluorophenylacetic acid (85068-28-6) → benzhydryl 2-<(4S)-4-(2,6-difluorophenylacetylamino)-3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate (128797-31-9)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; for 0.666667h; Ambient temperature;

DOI:10.1248/cpb.38.116

Reference yield: 42.0%

benzhydryl 2-<(4S)-4-(2,6-difluorophenylacetylamino)-3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate (128797-31-9) → sodium 2-<(4S)-4-(2,6-difluorophenylacetylamino)-3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate (128797-23-9)

Guidance literature:

With methoxybenzene; trifluoroacetic acid; In dichloromethane; at -10 ℃; for 5h;

DOI:10.1248/cpb.38.116

upstream raw materials:

benzhydryl 2-<(4S)-4-amino-3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate

2,6-difluorophenylacetic acid

Downstream raw materials:

sodium 2-<(4S)-4-(2,6-difluorophenylacetylamino)-3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate