Technology Process of 4-(3'α-benzyloxy-15'β-hydroxy-5'β-estran-17'β-yl)furan-2-carboxyaldehyde ethylene acetal
There total 12 articles about 4-(3'α-benzyloxy-15'β-hydroxy-5'β-estran-17'β-yl)furan-2-carboxyaldehyde ethylene acetal which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen; sodium acetate;
Lindlar's catalyst;
In
tetrahydrofuran; methanol;
for 6h;
under 2585.74 Torr;
DOI:10.1021/jm0505819
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: 3.0 g / NaBH4 / methanol; tetrahydrofuran / 20 °C
2.1: 78 percent / NaH / toluene / 6 h / Heating
3.1: pyridinium tribromide / tetrahydrofuran / 20 h / 4 °C
4.1: t-BuOK / benzene; dimethylsulfoxide / 20 h / 60 °C
5.1: 3.4 g / pyridinium p-toluenesulfonate; H2O / acetone
6.1: n-BuLi / tetrahydrofuran / 0.5 h / -70 °C
6.2: 40 percent / tetrahydrofuran / 1 h / -70 °C
7.1: 96 percent / pyridine; dimethylaminopyridine / 20 °C
8.1: 54 percent / CaCO3; H2O / acetone / 72 h / Heating
9.1: 99 percent / NaOAc; H2 / Pd/CaCO3 / tetrahydrofuran; methanol / 6 h / 2585.74 Torr
With
pyridine; dmap; sodium tetrahydroborate; n-butyllithium; potassium tert-butylate; water; hydrogen; sodium acetate; pyridinium p-toluenesulfonate; sodium hydride; pyridinium hydrobromide perbromide; calcium carbonate;
Lindlar's catalyst;
In
tetrahydrofuran; methanol; dimethyl sulfoxide; acetone; toluene; benzene;
DOI:10.1021/jm0505819
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 78 percent / NaH / toluene / 6 h / Heating
2.1: pyridinium tribromide / tetrahydrofuran / 20 h / 4 °C
3.1: t-BuOK / benzene; dimethylsulfoxide / 20 h / 60 °C
4.1: 3.4 g / pyridinium p-toluenesulfonate; H2O / acetone
5.1: n-BuLi / tetrahydrofuran / 0.5 h / -70 °C
5.2: 40 percent / tetrahydrofuran / 1 h / -70 °C
6.1: 96 percent / pyridine; dimethylaminopyridine / 20 °C
7.1: 54 percent / CaCO3; H2O / acetone / 72 h / Heating
8.1: 99 percent / NaOAc; H2 / Pd/CaCO3 / tetrahydrofuran; methanol / 6 h / 2585.74 Torr
With
pyridine; dmap; n-butyllithium; potassium tert-butylate; water; hydrogen; sodium acetate; pyridinium p-toluenesulfonate; sodium hydride; pyridinium hydrobromide perbromide; calcium carbonate;
Lindlar's catalyst;
In
tetrahydrofuran; methanol; dimethyl sulfoxide; acetone; toluene; benzene;
DOI:10.1021/jm0505819
