4-{(S)-2-(3-benzylureido)-2-[2-(thiophen-2-yl)thiazol-4-yl]ethyl}phenylsulfamic acid ammonium salt

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Chemical Name:4-{(S)-2-(3-benzylureido)-2-[2-(thiophen-2-yl)thiazol-4-yl]ethyl}phenylsulfamic acid ammonium salt
CAS No.:1235330-67-2
Molecular Formula:C₂₃H₂₂N₄O₄S₃*H₃N
Molecular Weight:531.681
Hs Code.:

Synonyms:4-{(S)-2-(3-benzylureido)-2-[2-(thiophen-2-yl)thiazol-4-yl]ethyl}phenylsulfamic acid ammonium salt

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Chemical Property of 4-{(S)-2-(3-benzylureido)-2-[2-(thiophen-2-yl)thiazol-4-yl]ethyl}phenylsulfamic acid ammonium salt

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Technology Process of 4-{(S)-2-(3-benzylureido)-2-[2-(thiophen-2-yl)thiazol-4-yl]ethyl}phenylsulfamic acid ammonium salt

There total 6 articles about 4-{(S)-2-(3-benzylureido)-2-[2-(thiophen-2-yl)thiazol-4-yl]ethyl}phenylsulfamic acid ammonium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₂₂N₄OS₂

: 1235330-67-2
4-{(S)-2-(3-benzylureido)-2-[2-(thiophen-2-yl)thiazol-4-yl]ethyl}phenylsulfamic acid ammonium salt

Guidance literature:: C₂₃H₂₂N₄OS₂; With pyridine-SO₃ complex; In pyridine; at 20 ℃; for 0.0833333h;

With ammonium hydroxide; In pyridine; water;

Reference yield:

: 1000394-83-1
1-benzyl-3-{(S)-2-(4-nitrophenyl)-1-[2-(thiophen-2-yl)thiazol-4-yl]ethyl}urea

: 1235330-67-2
4-{(S)-2-(3-benzylureido)-2-[2-(thiophen-2-yl)thiazol-4-yl]ethyl}phenylsulfamic acid ammonium salt

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / dichloromethane; methanol / 18 h

2: pyridine; sulfur trioxide pyridine complex / 0.08 h / 20 °C

With pyridine; hydrogen; sulfur trioxide pyridine complex; palladium 10% on activated carbon; In methanol; dichloromethane;

Reference yield:

: 33305-77-0
Boc-Phe(p-NO₂)-OH

: 1235330-67-2
4-{(S)-2-(3-benzylureido)-2-[2-(thiophen-2-yl)thiazol-4-yl]ethyl}phenylsulfamic acid ammonium salt

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 0.33 h / 0 °C

1.2: 3 h / 0 - 20 °C

2.1: hydrogen bromide / water; tetrahydrofuran / 1.5 h / 0 °C

3.1: acetonitrile / 5 h / Reflux

4.1: triethylamine / dichloromethane / 18 h / 20 °C

5.1: hydrogen / palladium 10% on activated carbon / dichloromethane; methanol / 18 h

6.1: pyridine; sulfur trioxide pyridine complex / 0.08 h / 20 °C

With pyridine; hydrogen bromide; hydrogen; sulfur trioxide pyridine complex; triethylamine; isobutyl chloroformate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;