1-(5-(1-(4-isopropylbenzyl)azetidin-3-yloxy)pyridin-2-yl)-4-(methylsulfonyl)piperazine

Base Information

Chemical Name:1-(5-(1-(4-isopropylbenzyl)azetidin-3-yloxy)pyridin-2-yl)-4-(methylsulfonyl)piperazine
CAS No.:1287684-98-3
Molecular Formula:C₂₃H₃₂N₄O₃S
Molecular Weight:444.598
Hs Code.:

Synonyms:1-(5-(1-(4-isopropylbenzyl)azetidin-3-yloxy)pyridin-2-yl)-4-(methylsulfonyl)piperazine

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Chemical Property of 1-(5-(1-(4-isopropylbenzyl)azetidin-3-yloxy)pyridin-2-yl)-4-(methylsulfonyl)piperazine

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Technology Process of 1-(5-(1-(4-isopropylbenzyl)azetidin-3-yloxy)pyridin-2-yl)-4-(methylsulfonyl)piperazine

There total 4 articles about 1-(5-(1-(4-isopropylbenzyl)azetidin-3-yloxy)pyridin-2-yl)-4-(methylsulfonyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1287685-85-1
1-(5-(azetidin-3-yloxy)pyridin-2-yl)-4-(methylsulfonyl)piperazine

: 122-03-2
(4-isopropylbenzaldehyde)

: 1287684-98-3
1-(5-(1-(4-isopropylbenzyl)azetidin-3-yloxy)pyridin-2-yl)-4-(methylsulfonyl)piperazine

Guidance literature:: 1-(5-(azetidin-3-yloxy)pyridin-2-yl)-4-(methylsulfonyl)piperazine; (4-isopropylbenzaldehyde); With sodium tris(acetoxy)borohydride; acetic acid; In 1,1-dichloroethane; at 20 ℃;

In 1,1-dichloroethane; at 100 ℃; for 0.0833333h; Microwave irradiation;

Reference yield:

: 1146089-80-6
tert-butyl 3-((6-bromopyridin-3-yl)oxy)azetidin-1-carboxylate

: 1287684-98-3
1-(5-(1-(4-isopropylbenzyl)azetidin-3-yloxy)pyridin-2-yl)-4-(methylsulfonyl)piperazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium t-butanolate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 4 h / 100 °C / Inert atmosphere; Sealed tube

2.1: hydrogen / palladium 10% on activated carbon / methanol / 8 h / 760.05 Torr

3.1: triethylamine / dichloromethane

3.2: 3 h / 20 °C

4.1: acetic acid; sodium tris(acetoxy)borohydride / 1,1-dichloroethane / 20 °C

4.2: silica-bound tosyl hydrazine / 0.08 h / 100 °C / Microwave irradiation

With hydrogen; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In methanol; 1,1-dichloroethane; dichloromethane; toluene;

Reference yield:

: 1287685-83-9
benzyl 4-(5-(1-(tert-butoxycarbonyl)azetidin-3-yloxy)pyridin-2-yl)piperazine-1-carboxylate

: 1287684-98-3
1-(5-(1-(4-isopropylbenzyl)azetidin-3-yloxy)pyridin-2-yl)-4-(methylsulfonyl)piperazine

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 8 h / 760.05 Torr

2.1: triethylamine / dichloromethane

2.2: 3 h / 20 °C

3.1: acetic acid; sodium tris(acetoxy)borohydride / 1,1-dichloroethane / 20 °C

3.2: silica-bound tosyl hydrazine / 0.08 h / 100 °C / Microwave irradiation

With hydrogen; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; palladium 10% on activated carbon; In methanol; 1,1-dichloroethane; dichloromethane;