(2S,4S)-2-(2-(4-bromophenyl)-2-oxoethyl) 1-tert-butyl 4-(methoxymethyl)pyrrolidine-1,2-dicarboxylate

Base Information

Chemical Name:(2S,4S)-2-(2-(4-bromophenyl)-2-oxoethyl) 1-tert-butyl 4-(methoxymethyl)pyrrolidine-1,2-dicarboxylate
CAS No.:1378388-14-7
Molecular Formula:C₂₀H₂₆BrNO₆
Molecular Weight:456.334
Hs Code.:

Synonyms:(2S,4S)-2-(2-(4-bromophenyl)-2-oxoethyl) 1-tert-butyl 4-(methoxymethyl)pyrrolidine-1,2-dicarboxylate

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Chemical Property of (2S,4S)-2-(2-(4-bromophenyl)-2-oxoethyl) 1-tert-butyl 4-(methoxymethyl)pyrrolidine-1,2-dicarboxylate

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Technology Process of (2S,4S)-2-(2-(4-bromophenyl)-2-oxoethyl) 1-tert-butyl 4-(methoxymethyl)pyrrolidine-1,2-dicarboxylate

There total 7 articles about (2S,4S)-2-(2-(4-bromophenyl)-2-oxoethyl) 1-tert-butyl 4-(methoxymethyl)pyrrolidine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1378388-16-9
(2S,4S)-N-(tert-butyloxycarbonyl)-4-(methoxymethyl)-pyrrolidine-2-carboxylic acid

: 99-73-0,132309-76-3
para-bromophenacyl bromide

: 1378388-14-7
(2S,4S)-2-(2-(4-bromophenyl)-2-oxoethyl) 1-tert-butyl 4-(methoxymethyl)pyrrolidine-1,2-dicarboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 0 - 25 ℃;

Reference yield:

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 1378388-14-7
(2S,4S)-2-(2-(4-bromophenyl)-2-oxoethyl) 1-tert-butyl 4-(methoxymethyl)pyrrolidine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / dichloromethane / 20 °C

2: Dess-Martin periodane / dichloromethane / 4 h / 0 - 20 °C

3: potassium carbonate / 0 - 20 °C

4: palladium on activated charcoal; hydrogen; magnesium oxide / methanol / 2 h / 20 °C

5: Dess-Martin periodane; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C

6: triethylamine / dichloromethane / 3 h / 20 °C

With palladium on activated charcoal; hydrogen; magnesium oxide; potassium carbonate; Dess-Martin periodane; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 74844-91-0
1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate

: 1378388-14-7
(2S,4S)-2-(2-(4-bromophenyl)-2-oxoethyl) 1-tert-butyl 4-(methoxymethyl)pyrrolidine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: Dess-Martin periodane / dichloromethane / 4 h / 0 - 20 °C

2: potassium carbonate / 0 - 20 °C

3: palladium on activated charcoal; hydrogen; magnesium oxide / methanol / 2 h / 20 °C

4: Dess-Martin periodane; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C

5: triethylamine / dichloromethane / 3 h / 20 °C

With palladium on activated charcoal; hydrogen; magnesium oxide; potassium carbonate; Dess-Martin periodane; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;