3-Methyl-4-[5-(2-methyl-5-trifluoromethyl-2H-pyrazol-3-yl)-1H-indol-2-yl]-benzoic acid methyl ester

Base Information

Chemical Name:3-Methyl-4-[5-(2-methyl-5-trifluoromethyl-2H-pyrazol-3-yl)-1H-indol-2-yl]-benzoic acid methyl ester
CAS No.:1279103-76-2
Molecular Formula:C₂₂H₁₈F₃N₃O₂
Molecular Weight:413.399
Hs Code.:

Synonyms:3-Methyl-4-[5-(2-methyl-5-trifluoromethyl-2H-pyrazol-3-yl)-1H-indol-2-yl]-benzoic acid methyl ester

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Chemical Property of 3-Methyl-4-[5-(2-methyl-5-trifluoromethyl-2H-pyrazol-3-yl)-1H-indol-2-yl]-benzoic acid methyl ester

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Technology Process of 3-Methyl-4-[5-(2-methyl-5-trifluoromethyl-2H-pyrazol-3-yl)-1H-indol-2-yl]-benzoic acid methyl ester

There total 9 articles about 3-Methyl-4-[5-(2-methyl-5-trifluoromethyl-2H-pyrazol-3-yl)-1H-indol-2-yl]-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1279106-69-2
2-(4-Methoxycarbonyl-2-methyl-phenyl)-5-(2-methyl-5-trifluoromethyl-2H-pyrazol-3-yl)-indole-1-carboxylic acid ethyl ester

: 1279103-76-2
3-Methyl-4-[5-(2-methyl-5-trifluoromethyl-2H-pyrazol-3-yl)-1H-indol-2-yl]-benzoic acid methyl ester

Guidance literature:: 2-(4-Methoxycarbonyl-2-methyl-phenyl)-5-(2-methyl-5-trifluoromethyl-2H-pyrazol-3-yl)-indole-1-carboxylic acid ethyl ester; With sodium hydroxide; In methanol; at 0 ℃; for 3h;

With hydrogenchloride; In water;

Reference yield:

: 59-48-3
2-oxoindole

: 1279103-76-2
3-Methyl-4-[5-(2-methyl-5-trifluoromethyl-2H-pyrazol-3-yl)-1H-indol-2-yl]-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: N-Bromosuccinimide / acetonitrile / 3 h / 0 °C

2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 16 h / 100 °C

3: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 4 h / 100 °C / Inert atmosphere

4: triethylamine / tetrahydrofuran / 0 - 20 °C

5: ammonium carbonate / N,N-dimethyl-formamide / 1 h / 0 - 25 °C

6: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C

7: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere

8: sodium hydroxide / methanol / 3 h / 0 °C

With N-Bromosuccinimide; potassium acetate; ammonium carbonate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 548466-05-3
trifluoro-methanesulfonic acid 2-methyl-5-trifluoromethyl-2H-pyrazol-3-yl ester

: 1279103-76-2
3-Methyl-4-[5-(2-methyl-5-trifluoromethyl-2H-pyrazol-3-yl)-1H-indol-2-yl]-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 4 h / 100 °C / Inert atmosphere

2: triethylamine / tetrahydrofuran / 0 - 20 °C

3: ammonium carbonate / N,N-dimethyl-formamide / 1 h / 0 - 25 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C

5: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere

6: sodium hydroxide / methanol / 3 h / 0 °C

With ammonium carbonate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;