<2R-(2β,3α)>-3-<(phenylmethoxy)methyl>oxiranecarboxaldehyde

Base Information

• Chemical Name: <2R-(2β,3α)>-3-<(phenylmethoxy)methyl>oxiranecarboxaldehyde
• CAS No.: 114925-54-1
• Molecular Formula: C₁₁H₁₂O₃
• Molecular Weight: 192.214
• Mol file: 114925-54-1.mol

Synonyms:<2R-(2β,3α)>-3-<(phenylmethoxy)methyl>oxiranecarboxaldehyde

Chemical Property of <2R-(2β,3α)>-3-<(phenylmethoxy)methyl>oxiranecarboxaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of <2R-(2β,3α)>-3-<(phenylmethoxy)methyl>oxiranecarboxaldehyde

There total 7 articles about <2R-(2β,3α)>-3-<(phenylmethoxy)methyl>oxiranecarboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

cis-4-benzyloxy-2,3-epoxy-1-butanol (87172-27-8) → (±)-3-((benzyloxy)methyl)oxirane-2-carbaldehyde (84573-21-7,87938-77-0,99945-63-8,113215-46-6,114925-54-1,127909-66-4,133321-78-5)

Guidance literature:

With dipyridinium dichromate; 4 A molecular sieve; In dichloromethane; for 4h; Ambient temperature;

DOI:10.1016/0040-4039(94)85219-7

Reference yield: 65.0%

<2R-(2β,3α)>-3-<(phenylmethoxy)methyl>oxiranemethanol (78513-15-2) → <2R-(2β,3α)>-3-<(phenylmethoxy)methyl>oxiranecarboxaldehyde (114925-54-1)

Guidance literature:

With N-methyl-2-indolinone; tetrapropylammonium perruthennate; 4 A molecular sieve; In dichloromethane; for 3.5h; Ambient temperature;

DOI:10.1021/jo00124a021

Reference yield:

4-benzyloxycrotonaldehyde (69152-87-0) → 3-benzyloxymethyl-oxirane-2-carbaldehyde + (2R,3S)-3-Benzyloxymethyl-oxirane-2-carbaldehyde (127909-66-4) + <2R-(2β,3α)>-3-<(phenylmethoxy)methyl>oxiranecarboxaldehyde (114925-54-1)

Guidance literature:

With (S)-2-{bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilanyl)oxy]methyl}pyrrolidine; dihydrogen peroxide; In dichloromethane; at 20 ℃; for 4h; Title compound not separated from byproducts;

DOI:10.1021/ja051808s

upstream raw materials:

cis-4-benzyloxy-2,3-epoxy-1-butanol

(Z)-4-benzyloxy-but-2-en-1-ol

benzyl bromide

<2R-(2β,3α)>-3-<(phenylmethoxy)methyl>oxiranemethanol

Downstream raw materials:

tret-butyl (5S)-5-((R)-2-benzyloxy-1-hydroxyethyl)-4-hydroxy-2-methyl-4,5-dihydrofuran-3-carboxylate

methyl (R)-5-(2-benzyloxy-1-hydroxyethyl)-2-methylfuran-3-carboxylate

(E)-ethyl 3-((2R,3R)-3-(benzyloxymethyl)oxiran-2-yl)acrylate

3-(4,6-di-O-benzyl-2,3-dideoxy-α-D-erythro-hex-2-enopyranosyl)-1-propene