(R)-4-((R)-1-(7-(3-fluoro-4-(trifluoromethoxy)phenyl)-1,6-naphthyridine-5-yloxy)ethyl)pyrrolidine-2-one

Base Information

Chemical Name:(R)-4-((R)-1-(7-(3-fluoro-4-(trifluoromethoxy)phenyl)-1,6-naphthyridine-5-yloxy)ethyl)pyrrolidine-2-one
CAS No.:1319737-89-7
Molecular Formula:C₂₁H₁₇F₄N₃O₃
Molecular Weight:435.378
Hs Code.:

Synonyms:(R)-4-((R)-1-(7-(3-fluoro-4-(trifluoromethoxy)phenyl)-1,6-naphthyridine-5-yloxy)ethyl)pyrrolidine-2-one

Suppliers and Price of (R)-4-((R)-1-(7-(3-fluoro-4-(trifluoromethoxy)phenyl)-1,6-naphthyridine-5-yloxy)ethyl)pyrrolidine-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-4-((R)-1-(7-(3-fluoro-4-(trifluoromethoxy)phenyl)-1,6-naphthyridine-5-yloxy)ethyl)pyrrolidine-2-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-4-((R)-1-(7-(3-fluoro-4-(trifluoromethoxy)phenyl)-1,6-naphthyridine-5-yloxy)ethyl)pyrrolidine-2-one

There total 9 articles about (R)-4-((R)-1-(7-(3-fluoro-4-(trifluoromethoxy)phenyl)-1,6-naphthyridine-5-yloxy)ethyl)pyrrolidine-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 1319736-55-4
(R)-4-((R)-1-hydroxyethyl)pyrrolidine-2-one

: 1319737-41-1
5-chloro-7-(4-(trifluoromethoxy)phenyl)-1,6-naphthyridine

: 1319737-89-7
(R)-4-((R)-1-(7-(3-fluoro-4-(trifluoromethoxy)phenyl)-1,6-naphthyridine-5-yloxy)ethyl)pyrrolidine-2-one

Guidance literature:: (R)-4-((R)-1-hydroxyethyl)pyrrolidine-2-one; With sodium hydride; In N,N-dimethyl acetamide; at 20 ℃; for 0.25h;

5-chloro-7-(4-(trifluoromethoxy)phenyl)-1,6-naphthyridine; In N,N-dimethyl acetamide; at 40 ℃; for 3h;

Reference yield:

: 99735-43-0,96449-93-3,99735-44-1
(3R)-1-((R)-1-phenylethyl)-5-oxo-3-pyrrolidinecarboxylic acid

: 1319737-89-7
(R)-4-((R)-1-(7-(3-fluoro-4-(trifluoromethoxy)phenyl)-1,6-naphthyridine-5-yloxy)ethyl)pyrrolidine-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: benzotriazol-1-ol; 4-methyl-morpholine; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / N,N-dimethyl-formamide / 0 - 20 °C

2.1: diethyl ether; tetrahydrofuran / -10 °C / Inert atmosphere

3.1: lithium dihydrido borata-bicyclo[3.3.0]nonane / dichloromethane; tetrahydrofuran / -50 - -30 °C / Inert atmosphere

3.2: 20 °C / Aqueous phosphate buffer

4.1: trifluoroacetic acid / 1.5 h / 150 °C / Microwave irradiation

5.1: sodium hydride / N,N-dimethyl acetamide / 0.25 h / 20 °C

5.2: 3 h / 40 °C

With 4-methyl-morpholine; sodium hydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; lithium dihydrido borata-bicyclo[3.3.0]nonane; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;

Reference yield:

: 105529-58-6
4-bromo-2-fluoro-1-(trifluoromethoxy)benzene

: 1319737-89-7
(R)-4-((R)-1-(7-(3-fluoro-4-(trifluoromethoxy)phenyl)-1,6-naphthyridine-5-yloxy)ethyl)pyrrolidine-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,N-dimethyl acetamide / 140 - 150 °C

2.1: lithium diisopropyl amide / n-heptane; tetrahydrofuran; ethylbenzene / 1.67 h / -70 - 0 °C / Inert atmosphere

2.2: -70 - 20 °C / Inert atmosphere

3.1: N,N-diethylaniline; trichlorophosphate / 120 °C

4.1: sodium hydride / N,N-dimethyl acetamide / 0.25 h / 20 °C

4.2: 3 h / 40 °C

With sodium hydride; N,N-diethylaniline; lithium diisopropyl amide; trichlorophosphate; In tetrahydrofuran; n-heptane; N,N-dimethyl acetamide; ethylbenzene;