3-(4-methoxyphenyl)-1-[2,4-bis(benzyloxy)phenyl]-2-[1,2,3-⁽¹³⁾C₃]propen-1-one

Base Information

• Chemical Name: 3-(4-methoxyphenyl)-1-[2,4-bis(benzyloxy)phenyl]-2-[1,2,3-⁽¹³⁾C₃]propen-1-one
• CAS No.: 1229516-39-5
• Molecular Formula: C₃₀H₂₆O₄
• Molecular Weight: 453.501
• Mol file: 1229516-39-5.mol

Synonyms:3-(4-methoxyphenyl)-1-[2,4-bis(benzyloxy)phenyl]-2-[1,2,3-⁽¹³⁾C₃]propen-1-one

Chemical Property of 3-(4-methoxyphenyl)-1-[2,4-bis(benzyloxy)phenyl]-2-[1,2,3-⁽¹³⁾C₃]propen-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-methoxyphenyl)-1-[2,4-bis(benzyloxy)phenyl]-2-[1,2,3-⁽¹³⁾C₃]propen-1-one

There total 5 articles about 3-(4-methoxyphenyl)-1-[2,4-bis(benzyloxy)phenyl]-2-[1,2,3-⁽¹³⁾C₃]propen-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2,4-[1',2'-(13)C2]dibenzyloxyacetophenone (1229516-29-3) + α-[13C]-4-methoxybenzaldehyde (95537-93-2) → 3-(4-methoxyphenyl)-1-[2,4-bis(benzyloxy)phenyl]-2-[1,2,3-(13)C3]propen-1-one (1229516-39-5)

Guidance literature:

With potassium hydroxide; In tetrahydrofuran; methanol; for 6h; Inert atmosphere; Reflux;

DOI:10.1002/jlcr.1732

Reference yield:

(13C)-4-methoxybenzonitrile (1333245-00-3) → 3-(4-methoxyphenyl)-1-[2,4-bis(benzyloxy)phenyl]-2-[1,2,3-(13)C3]propen-1-one (1229516-39-5)

Guidance literature:

Multi-step reaction with 2 steps

1: diisobutylaluminium hydride / tetrahydrofuran / 20 °C

2: potassium hydroxide / tetrahydrofuran; methanol / 6 h / Inert atmosphere; Reflux

With diisobutylaluminium hydride; potassium hydroxide; In tetrahydrofuran; methanol;

DOI:10.1002/jlcr.1732

Reference yield:

para-iodoanisole (696-62-8) → 3-(4-methoxyphenyl)-1-[2,4-bis(benzyloxy)phenyl]-2-[1,2,3-(13)C3]propen-1-one (1229516-39-5)

Guidance literature:

Multi-step reaction with 3 steps

1: palladium diacetate; calcium hydroxide / N,N-dimethyl-formamide / 16 h / Reflux

2: diisobutylaluminium hydride / tetrahydrofuran / 20 °C

3: potassium hydroxide / tetrahydrofuran; methanol / 6 h / Inert atmosphere; Reflux

With palladium diacetate; diisobutylaluminium hydride; potassium hydroxide; calcium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1002/jlcr.1732

upstream raw materials:

2,4-[1',2'-⁽¹³⁾C₂]dibenzyloxyacetophenone

α-[¹³C]-4-methoxybenzaldehyde

(¹³C)-4-methoxybenzonitrile

para-iodoanisole

Downstream raw materials:

[2,3,4-⁽¹³⁾C₃]formononetin