N-(2-(3,4-dichlorophenylamino)ethyl)-2-(4-(methylsulfonamido)phenoxy)acetamide

Base Information

Chemical Name:N-(2-(3,4-dichlorophenylamino)ethyl)-2-(4-(methylsulfonamido)phenoxy)acetamide
CAS No.:1097212-97-9
Molecular Formula:C₁₇H₁₉Cl₂N₃O₄S
Molecular Weight:432.328
Hs Code.:

Synonyms:N-(2-(3,4-dichlorophenylamino)ethyl)-2-(4-(methylsulfonamido)phenoxy)acetamide

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Chemical Property of N-(2-(3,4-dichlorophenylamino)ethyl)-2-(4-(methylsulfonamido)phenoxy)acetamide

Chemical Property:

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Technology Process of N-(2-(3,4-dichlorophenylamino)ethyl)-2-(4-(methylsulfonamido)phenoxy)acetamide

There total 6 articles about N-(2-(3,4-dichlorophenylamino)ethyl)-2-(4-(methylsulfonamido)phenoxy)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 103790-20-1
2-(4-(methylsulfonamido)phenoxy)acetic acid

: 40779-26-8
N₁-(3,4-dichlorophenyl)ethane-1,2-diamine

: 1097212-97-9
N-(2-(3,4-dichlorophenylamino)ethyl)-2-(4-(methylsulfonamido)phenoxy)acetamide

Guidance literature:: 2-(4-(methylsulfonamido)phenoxy)acetic acid; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 ℃; for 0.75h;

N₁-(3,4-dichlorophenyl)ethane-1,2-diamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1016/j.bmc.2009.05.085

Reference yield:

: 1192366-04-3
methyl 2-(4-(methylsulfonamido)phenoxy)acetate

: 1097212-97-9
N-(2-(3,4-dichlorophenylamino)ethyl)-2-(4-(methylsulfonamido)phenoxy)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol; sodium hydroxide / 12 h / 20 °C

2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.75 h / 0 °C

2.2: 0 - 20 °C

With methanol; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2009.05.085

Reference yield:

: 1798-11-4
4-nitrophenoxyacetic acid

: 1097212-97-9
N-(2-(3,4-dichlorophenylamino)ethyl)-2-(4-(methylsulfonamido)phenoxy)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / 0.17 h / -10 °C

1.2: 1 h

2.1: 5% Pd(II)/C(eggshell); hydrogen / methanol / 12 h / 20 °C

3.1: pyridine / 0 - 20 °C

4.1: methanol; sodium hydroxide / 12 h / 20 °C

5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.75 h / 0 °C

5.2: 0 - 20 °C

With pyridine; methanol; dmap; thionyl chloride; 5% Pd(II)/C(eggshell); hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2009.05.085