(S)-2-({(S)-2-[(2-{(S)-2-[(2-tert-Butoxycarbonylamino-acetyl)-methyl-amino]-4-methyl-pentanoylamino}-acetyl)-methyl-amino]-3-methyl-butyryl}-methyl-amino)-3-(4-methoxy-phenyl)-propionic acid benzyl ester

Base Information

• Chemical Name: (S)-2-({(S)-2-[(2-{(S)-2-[(2-tert-Butoxycarbonylamino-acetyl)-methyl-amino]-4-methyl-pentanoylamino}-acetyl)-methyl-amino]-3-methyl-butyryl}-methyl-amino)-3-(4-methoxy-phenyl)-propionic acid benzyl ester
• CAS No.: 187806-98-0
• Molecular Formula: C₄₀H₅₉N₅O₉
• Molecular Weight: 753.937

Synonyms:(S)-2-({(S)-2-[(2-{(S)-2-[(2-tert-Butoxycarbonylamino-acetyl)-methyl-amino]-4-methyl-pentanoylamino}-acetyl)-methyl-amino]-3-methyl-butyryl}-methyl-amino)-3-(4-methoxy-phenyl)-propionic acid benzyl ester

Chemical Property of (S)-2-({(S)-2-[(2-{(S)-2-[(2-tert-Butoxycarbonylamino-acetyl)-methyl-amino]-4-methyl-pentanoylamino}-acetyl)-methyl-amino]-3-methyl-butyryl}-methyl-amino)-3-(4-methoxy-phenyl)-propionic acid benzyl ester

Chemical Property:

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Technology Process of (S)-2-({(S)-2-[(2-{(S)-2-[(2-tert-Butoxycarbonylamino-acetyl)-methyl-amino]-4-methyl-pentanoylamino}-acetyl)-methyl-amino]-3-methyl-butyryl}-methyl-amino)-3-(4-methoxy-phenyl)-propionic acid benzyl ester

There total 7 articles about (S)-2-({(S)-2-[(2-{(S)-2-[(2-tert-Butoxycarbonylamino-acetyl)-methyl-amino]-4-methyl-pentanoylamino}-acetyl)-methyl-amino]-3-methyl-butyryl}-methyl-amino)-3-(4-methoxy-phenyl)-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

{(S)-2-[(2-tert-Butoxycarbonylamino-acetyl)-methyl-amino]-4-methyl-pentanoylamino}-acetic acid (112661-65-1) + (S)-3-(4-Methoxy-phenyl)-2-[methyl-((S)-3-methyl-2-methylamino-butyryl)-amino]-propionic acid benzyl ester; hydrochloride → (S)-2-({(S)-2-[(2-{(S)-2-[(2-tert-Butoxycarbonylamino-acetyl)-methyl-amino]-4-methyl-pentanoylamino}-acetyl)-methyl-amino]-3-methyl-butyryl}-methyl-amino)-3-(4-methoxy-phenyl)-propionic acid benzyl ester (187806-98-0)

Guidance literature:

With isobutyl chloroformate;

DOI:10.1021/ja963857y

Reference yield:

t-Boc-L-valine (13734-41-3) → (S)-2-({(S)-2-[(2-{(S)-2-[(2-tert-Butoxycarbonylamino-acetyl)-methyl-amino]-4-methyl-pentanoylamino}-acetyl)-methyl-amino]-3-methyl-butyryl}-methyl-amino)-3-(4-methoxy-phenyl)-propionic acid benzyl ester (187806-98-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 89 percent / isobutylchloroformate

2: 100 percent / NaOH

3: 92 percent / NaH

4: 66 percent / SOCl₂

5: 61 percent / isobutyl chloroformate

With sodium hydroxide; thionyl chloride; sodium hydride; isobutyl chloroformate;

DOI:10.1021/ja963857y

Reference yield:

L-tyrosine ethyl ester (949-67-7) → (S)-2-({(S)-2-[(2-{(S)-2-[(2-tert-Butoxycarbonylamino-acetyl)-methyl-amino]-4-methyl-pentanoylamino}-acetyl)-methyl-amino]-3-methyl-butyryl}-methyl-amino)-3-(4-methoxy-phenyl)-propionic acid benzyl ester (187806-98-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 89 percent / isobutylchloroformate

2: 100 percent / NaOH

3: 92 percent / NaH

4: 66 percent / SOCl₂

5: 61 percent / isobutyl chloroformate

With sodium hydroxide; thionyl chloride; sodium hydride; isobutyl chloroformate;

DOI:10.1021/ja963857y

upstream raw materials:

{(S)-2-[(2-tert-Butoxycarbonylamino-acetyl)-methyl-amino]-4-methyl-pentanoylamino}-acetic acid

t-Boc-L-valine

N^α-tert-butoxycarbonylvalyltyrosine

L-tyrosine ethyl ester

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