<9(S),12(S)>-α,α-difluoro-β-hydroxy-9-(1-methylethyl)-4,7,10-trioxo-N-(phenylmethyl)-2-oxa-5,8,11-triazabicyclo<12,2,2>octadeca-14,16,17-triene-12-propanamide

Base Information

Chemical Name:<9(S),12(S)>-α,α-difluoro-β-hydroxy-9-(1-methylethyl)-4,7,10-trioxo-N-(phenylmethyl)-2-oxa-5,8,11-triazabicyclo<12,2,2>octadeca-14,16,17-triene-12-propanamide
CAS No.:158342-63-3
Molecular Formula:C₂₇H₃₂F₂N₄O₆
Molecular Weight:546.571
Hs Code.:

<9(S),12(S)>-α,α-difluoro-β-hydroxy-9-(1-methylethyl)-4,7,10-trioxo-N-(phenylmethyl)-2-oxa-5,8,11-triazabicyclo<12,2,2>octadeca-14,16,17-triene-12-propanamide

Synonyms:<9(S),12(S)>-α,α-difluoro-β-hydroxy-9-(1-methylethyl)-4,7,10-trioxo-N-(phenylmethyl)-2-oxa-5,8,11-triazabicyclo<12,2,2>octadeca-14,16,17-triene-12-propanamide

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Chemical Property of <9(S),12(S)>-α,α-difluoro-β-hydroxy-9-(1-methylethyl)-4,7,10-trioxo-N-(phenylmethyl)-2-oxa-5,8,11-triazabicyclo<12,2,2>octadeca-14,16,17-triene-12-propanamide

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Technology Process of <9(S),12(S)>-α,α-difluoro-β-hydroxy-9-(1-methylethyl)-4,7,10-trioxo-N-(phenylmethyl)-2-oxa-5,8,11-triazabicyclo<12,2,2>octadeca-14,16,17-triene-12-propanamide

There total 6 articles about <9(S),12(S)>-α,α-difluoro-β-hydroxy-9-(1-methylethyl)-4,7,10-trioxo-N-(phenylmethyl)-2-oxa-5,8,11-triazabicyclo<12,2,2>octadeca-14,16,17-triene-12-propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (4-{(2S,3S)-2-[(S)-2-(2-Amino-acetylamino)-3-methyl-butyrylamino]-4-benzylcarbamoyl-4,4-difluoro-3-hydroxy-butyl}-phenoxy)-acetic acid pentafluorophenyl ester; hydrochloride

: 158342-63-3
<9(S),12(S)>-α,α-difluoro-β-hydroxy-9-(1-methylethyl)-4,7,10-trioxo-N-(phenylmethyl)-2-oxa-5,8,11-triazabicyclo<12,2,2>octadeca-14,16,17-triene-12-propanamide

Guidance literature:: With sodium hydrogencarbonate; In dichloromethane; for 72h; Yield given;
DOI:10.1021/jm00048a004

Reference yield:

: 1963-21-9,6491-59-4
L-glycyl-L-valine

: 158342-63-3
<9(S),12(S)>-α,α-difluoro-β-hydroxy-9-(1-methylethyl)-4,7,10-trioxo-N-(phenylmethyl)-2-oxa-5,8,11-triazabicyclo<12,2,2>octadeca-14,16,17-triene-12-propanamide

Guidance literature:: Multi-step reaction with 6 steps

1: Et₃N / tetrahydrofuran

2: 1-hydroxybenzotriazole hydrate, N-methylmorpholine, EDC / CH₂Cl₂; dimethylformamide / 72 h

3: LiOH*H₂O / methanol; H₂O / 4 h

4: EDC / CH₂Cl₂; dimethylsulfoxide-d6 / 72 h

5: 4 N HCl / dioxane / 2 h

6: aq. NaHCO₃ / CH₂Cl₂ / 72 h

With 4-methyl-morpholine; hydrogenchloride; lithium hydroxide; sodium hydrogencarbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1-hydroxybenzotriazol-hydrate; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dimethylsulfoxide-d6; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00048a004

Reference yield:

: 28334-73-8
(2S)-2-[[2-(tert-butoxycarbonylamino)acetyl]amino]-3-methylbutanoic acid

: 158342-63-3
<9(S),12(S)>-α,α-difluoro-β-hydroxy-9-(1-methylethyl)-4,7,10-trioxo-N-(phenylmethyl)-2-oxa-5,8,11-triazabicyclo<12,2,2>octadeca-14,16,17-triene-12-propanamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1-hydroxybenzotriazole hydrate, N-methylmorpholine, EDC / CH₂Cl₂; dimethylformamide / 72 h

2: LiOH*H₂O / methanol; H₂O / 4 h

3: EDC / CH₂Cl₂; dimethylsulfoxide-d6 / 72 h

4: 4 N HCl / dioxane / 2 h

5: aq. NaHCO₃ / CH₂Cl₂ / 72 h

With 4-methyl-morpholine; hydrogenchloride; lithium hydroxide; sodium hydrogencarbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1-hydroxybenzotriazol-hydrate; In 1,4-dioxane; methanol; dimethylsulfoxide-d6; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00048a004