2-[1-(2-aminoethyl)hexahydro-1H-azepin-4-yl]-4-[(4-chlorophenyl)methyl]-1(2H)-phthalazinone hydrochloride

Base Information

Chemical Name:2-[1-(2-aminoethyl)hexahydro-1H-azepin-4-yl]-4-[(4-chlorophenyl)methyl]-1(2H)-phthalazinone hydrochloride
CAS No.:955359-91-8
Molecular Formula:C₂₃H₂₇ClN₄O*ClH
Molecular Weight:447.408
Hs Code.:

Synonyms:2-[1-(2-aminoethyl)hexahydro-1H-azepin-4-yl]-4-[(4-chlorophenyl)methyl]-1(2H)-phthalazinone hydrochloride

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Chemical Property of 2-[1-(2-aminoethyl)hexahydro-1H-azepin-4-yl]-4-[(4-chlorophenyl)methyl]-1(2H)-phthalazinone hydrochloride

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Technology Process of 2-[1-(2-aminoethyl)hexahydro-1H-azepin-4-yl]-4-[(4-chlorophenyl)methyl]-1(2H)-phthalazinone hydrochloride

There total 8 articles about 2-[1-(2-aminoethyl)hexahydro-1H-azepin-4-yl]-4-[(4-chlorophenyl)methyl]-1(2H)-phthalazinone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 955359-90-7
1,1-dimethylethyl (2-{4-[4-[(4-chlorophenyl)methyl]-1-oxo-2(1H)-phthalazinyl]hexahydro-1H-azepin-1-yl}ethyl)carbamate

: 955359-91-8
2-[1-(2-aminoethyl)hexahydro-1H-azepin-4-yl]-4-[(4-chlorophenyl)methyl]-1(2H)-phthalazinone hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 955359-87-2
1,1-dimethylethyl 4-[4-[(4-chlorophenyl)methyl]-1-oxo-2(1H)-phthalazinyl]hexahydro-1H-azepine-1-carboxylate

: 955359-91-8
2-[1-(2-aminoethyl)hexahydro-1H-azepin-4-yl]-4-[(4-chlorophenyl)methyl]-1(2H)-phthalazinone hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; sodium iodide / acetone / 66 °C / Heating / reflux

3: hydrogenchloride / 1,4-dioxane; dichloromethane / 2 h / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; sodium iodide; In 1,4-dioxane; dichloromethane; acetone;

Reference yield:

: 478832-21-2
4-hydroxy-hexahydro-1H-azepine-1-carboxylic acid 1,1-dimethylethyl ester

: 955359-91-8
2-[1-(2-aminoethyl)hexahydro-1H-azepin-4-yl]-4-[(4-chlorophenyl)methyl]-1(2H)-phthalazinone hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 3.58 h / -20 - 20 °C

2: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; sodium iodide / acetone / 66 °C / Heating / reflux

4: hydrogenchloride / 1,4-dioxane; dichloromethane / 2 h / 20 °C

With hydrogenchloride; di-isopropyl azodicarboxylate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium iodide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetone;