15-tert-butyl-5,7-bis[2-isocyano-2-(p-tolylsulfonyl)ethyl][3.3]metacyclophane

Base Information

Chemical Name:15-tert-butyl-5,7-bis[2-isocyano-2-(p-tolylsulfonyl)ethyl][3.3]metacyclophane
CAS No.:936365-91-2
Molecular Formula:C₄₂H₄₆N₂O₄S₂
Molecular Weight:706.97
Hs Code.:

Synonyms:15-tert-butyl-5,7-bis[2-isocyano-2-(p-tolylsulfonyl)ethyl][3.3]metacyclophane

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Chemical Property of 15-tert-butyl-5,7-bis[2-isocyano-2-(p-tolylsulfonyl)ethyl][3.3]metacyclophane

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Technology Process of 15-tert-butyl-5,7-bis[2-isocyano-2-(p-tolylsulfonyl)ethyl][3.3]metacyclophane

There total 7 articles about 15-tert-butyl-5,7-bis[2-isocyano-2-(p-tolylsulfonyl)ethyl][3.3]metacyclophane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 936365-90-1
15-tert-butyl-5,7-bis(bromomethyl)[3.3]metacyclophane

: 38622-91-2,36635-61-7
[(p-methylphenyl)sulfonylmethyl]isonitrile

: 936365-91-2
15-tert-butyl-5,7-bis[2-isocyano-2-(p-tolylsulfonyl)ethyl][3.3]metacyclophane

Guidance literature:: With sodium hydroxide; tetra-(n-butyl)ammonium iodide; In dichloromethane; water; at 0 - 20 ℃;
DOI:10.1021/jo062220m

Reference yield:

: C₂₄H₃₂O₂

: 936365-91-2
15-tert-butyl-5,7-bis[2-isocyano-2-(p-tolylsulfonyl)ethyl][3.3]metacyclophane

Guidance literature:: Multi-step reaction with 2 steps

1: PBr₃ / benzene / 20 °C

2: 58 percent / n-Bu₄NI; NaOH / CH₂Cl₂; H₂O / 0 - 20 °C

With sodium hydroxide; phosphorus tribromide; tetra-(n-butyl)ammonium iodide; In dichloromethane; water; benzene;
DOI:10.1021/jo062220m

Reference yield:

: 936365-76-3
dimethyl 4,6-bis(bromomethyl)benzene-1,3-dicarboxylate

: 936365-91-2
15-tert-butyl-5,7-bis[2-isocyano-2-(p-tolylsulfonyl)ethyl][3.3]metacyclophane

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-Bu₄NI; NaOH / CH₂Cl₂; H₂O / Heating

1.2: 44 percent / aq. HCl / 20 °C

2.1: hydrazine hydrate; KOH / bis-(2-hydroxy-ethyl) ether / 130 - 200 °C

2.2: aq. HCl / bis-(2-hydroxy-ethyl) ether

3.1: H₂SO₄ / benzene / Heating

4.1: LiAlH₄ / tetrahydrofuran / Heating

5.1: PBr₃ / benzene / 20 °C

6.1: 58 percent / n-Bu₄NI; NaOH / CH₂Cl₂; H₂O / 0 - 20 °C

With potassium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; sulfuric acid; phosphorus tribromide; tetra-(n-butyl)ammonium iodide; hydrazine hydrate; In tetrahydrofuran; dichloromethane; water; diethylene glycol; benzene; 2.1: Wolff-Kishner reduction;
DOI:10.1021/jo062220m