4-methyl-5-oxyethyl thiazol diphosphate

Base Information

• Chemical Name: 4-methyl-5-oxyethyl thiazol diphosphate
• CAS No.: 2606-90-8
• Molecular Formula: C₆H₁₁NO₇P₂S
• Molecular Weight: 303.169
• Mol file: 2606-90-8.mol

Synonyms:4-methyl-5-oxyethyl thiazol diphosphate

Chemical Property of 4-methyl-5-oxyethyl thiazol diphosphate

Chemical Property:

• Melting Point: >136°C (dec.)
• Boiling Point: 550.3±52.0 °C(Predicted)
• Density: 1.734±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

4-Methyl-5-oxyethylThiazolDiphosphateAmmoniumSalt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 4-Methyl-5-oxyethyl Thiazol Diphosphate Ammonium Salt is a useful reagent in the enzymic synthesis of thiamine. An?Inhibitor of carboxylase.

Technology Process of 4-methyl-5-oxyethyl thiazol diphosphate

There total 3 articles about 4-methyl-5-oxyethyl thiazol diphosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-hydroxyethyl-4-methylthiazole (137-00-8,8042-97-5) → 4-methyl-5-oxyethyl thiazol diphosphate (2606-90-8)

Guidance literature:

With PPA; magnesium chloride; at 110 - 120 ℃; Behandeln des Reaktionsprodukts mit wss. HCl;

DOI:10.1021/ja01262a016

Reference yield:

diphosphoric acid 1,1-dibenzyl ester 2-[2-(4-methyl-thiazol-5-yl)-ethyl] ester; cyclohexylamine salt (4066-53-9) → 4-methyl-5-oxyethyl thiazol diphosphate (2606-90-8)

Guidance literature:

Multistep reaction; (i) ion exchange resin +-form>, (ii) H2, PdCl2, MeOH, (iii) ion exchange resin --form>;

Reference yield:

→ 4-methyl-5-oxyethyl thiazol diphosphate (2606-90-8)

Guidance literature:

Triphospho-4-methyl-5-(β-hydroxy-ethyl)-thiazol-phosphat, 2 N HCl;

upstream raw materials:

5-hydroxyethyl-4-methylthiazole

diphosphoric acid 1,1-dibenzyl ester 2-[2-(4-methyl-thiazol-5-yl)-ethyl] ester; cyclohexylamine salt

Downstream raw materials:

thiamine diphosphate