di-tert-butyl N-{4-[4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-1-methanesulfonylbutyl]benzoyl}-L-glutamate

Base Information

Chemical Name:di-tert-butyl N-{4-[4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-1-methanesulfonylbutyl]benzoyl}-L-glutamate
CAS No.:852475-41-3
Molecular Formula:C₂₉H₄₃N₅O₈S
Molecular Weight:621.755
Hs Code.:

Synonyms:di-tert-butyl N-{4-[4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-1-methanesulfonylbutyl]benzoyl}-L-glutamate

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Chemical Property of di-tert-butyl N-{4-[4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-1-methanesulfonylbutyl]benzoyl}-L-glutamate

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Technology Process of di-tert-butyl N-{4-[4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-1-methanesulfonylbutyl]benzoyl}-L-glutamate

There total 5 articles about di-tert-butyl N-{4-[4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-1-methanesulfonylbutyl]benzoyl}-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 852475-39-9
4-[4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-1-methanesulfonylbutyl]benzoic acid

: 32677-01-3
L-glutamic acid di-tert-butyl ester hydrochloride

: 852475-41-3
di-tert-butyl N-{4-[4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-1-methanesulfonylbutyl]benzoyl}-L-glutamate

Guidance literature:: With sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 25 ℃;
DOI:10.1016/j.bmc.2004.12.004

Reference yield:

: 852475-31-1
methyl 4-(4-bromo-1-methanesulfonylbutyl)benzoate

: 852475-41-3
di-tert-butyl N-{4-[4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-1-methanesulfonylbutyl]benzoyl}-L-glutamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaH / dimethylformamide / 0.5 h / 0 °C

1.2: 70 percent / dimethylformamide / 2 h / 25 °C

2.1: 58 percent / NaOCH₃ / methanol; dimethylformamide / 16 h / 75 °C

3.1: 100 percent / LiOH*H₂O / methanol; H₂O / 24 h / 25 °C

4.1: 45 percent / NaHCO₃; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 25 °C

With lithium hydroxide; sodium methylate; sodium hydride; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2004.12.004

Reference yield:

: 852475-34-4
methyl 4-(5-cyano-5-ethoxycarbonyl-1-methanesulfonylpentyl)benzoate

: 852475-41-3
di-tert-butyl N-{4-[4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-1-methanesulfonylbutyl]benzoyl}-L-glutamate

Guidance literature:: Multi-step reaction with 3 steps

1: 58 percent / NaOCH₃ / methanol; dimethylformamide / 16 h / 75 °C

2: 100 percent / LiOH*H₂O / methanol; H₂O / 24 h / 25 °C

3: 45 percent / NaHCO₃; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 25 °C

With lithium hydroxide; sodium methylate; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2004.12.004