2R-amino-1-(tert-butyldimethylsiloxy)methyl-2-(4-methoxyphenyl)-(1R)-ethyl 4-nitrobenzoate

Base Information

Chemical Name:2R-amino-1-(tert-butyldimethylsiloxy)methyl-2-(4-methoxyphenyl)-(1R)-ethyl 4-nitrobenzoate
CAS No.:635313-43-8
Molecular Formula:C₂₈H₄₀N₂O₈Si
Molecular Weight:560.72
Hs Code.:

Synonyms:2R-amino-1-(tert-butyldimethylsiloxy)methyl-2-(4-methoxyphenyl)-(1R)-ethyl 4-nitrobenzoate

Suppliers and Price of 2R-amino-1-(tert-butyldimethylsiloxy)methyl-2-(4-methoxyphenyl)-(1R)-ethyl 4-nitrobenzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2R-amino-1-(tert-butyldimethylsiloxy)methyl-2-(4-methoxyphenyl)-(1R)-ethyl 4-nitrobenzoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2R-amino-1-(tert-butyldimethylsiloxy)methyl-2-(4-methoxyphenyl)-(1R)-ethyl 4-nitrobenzoate

There total 10 articles about 2R-amino-1-(tert-butyldimethylsiloxy)methyl-2-(4-methoxyphenyl)-(1R)-ethyl 4-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.5%

: 635313-42-7
3R-(tert-butoxycarbonyl)-amino-3-(4-methoxyphenyl)-2S-propane-1-(tert-butyl dimethylsiloxy)-2-ol

: 62-23-7
4-nitro-benzoic acid

: 635313-43-8
2R-amino-1-(tert-butyldimethylsiloxy)methyl-2-(4-methoxyphenyl)-(1R)-ethyl 4-nitrobenzoate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 24h;
DOI:10.1081/SCC-120022181

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 635313-43-8
2R-amino-1-(tert-butyldimethylsiloxy)methyl-2-(4-methoxyphenyl)-(1R)-ethyl 4-nitrobenzoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: 6.6 g / Et₃N / tetrahydrofuran / 8 h / 20 °C

2.1: 99 percent / potassium carbonate / dimethylformamide / 7 h / 20 °C

3.1: 83.9 percent / NaBH₄; LiCl / ethanol; tetrahydrofuran / 16 h / 20 °C

4.1: oxalyl chloride; DMSO; N,N-diisopropylethyl amine / CH₂Cl₂ / -78 - 0 °C

5.1: 0.33 g / CH₂Cl₂; tetrahydrofuran / 20 °C

6.1: O₃ / CH₂Cl₂

6.2: 72.37 percent / NaBH₄ / methanol

7.1: 83 percent / imidazole / CH₂Cl₂ / 2 h

8.1: 63.5 percent / triphenyl phosphine; diisopropyl azodicarboxylate / tetrahydrofuran / 24 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; oxalyl dichloride; di-isopropyl azodicarboxylate; potassium carbonate; ozone; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium chloride; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; 4.1: Swern oxidation / 5.1: Grignard reaction / 8.1: Mitsunobu reaction;
DOI:10.1081/SCC-120022181

Reference yield:

: 22818-40-2
D-4-hydroxyphenylglycine

: 635313-43-8
2R-amino-1-(tert-butyldimethylsiloxy)methyl-2-(4-methoxyphenyl)-(1R)-ethyl 4-nitrobenzoate

Guidance literature:: Multi-step reaction with 9 steps

1.1: acetyl chloride / 3 h / Heating

2.1: 6.6 g / Et₃N / tetrahydrofuran / 8 h / 20 °C

3.1: 99 percent / potassium carbonate / dimethylformamide / 7 h / 20 °C

4.1: 83.9 percent / NaBH₄; LiCl / ethanol; tetrahydrofuran / 16 h / 20 °C

5.1: oxalyl chloride; DMSO; N,N-diisopropylethyl amine / CH₂Cl₂ / -78 - 0 °C

6.1: 0.33 g / CH₂Cl₂; tetrahydrofuran / 20 °C

7.1: O₃ / CH₂Cl₂

7.2: 72.37 percent / NaBH₄ / methanol

8.1: 83 percent / imidazole / CH₂Cl₂ / 2 h

9.1: 63.5 percent / triphenyl phosphine; diisopropyl azodicarboxylate / tetrahydrofuran / 24 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; oxalyl dichloride; di-isopropyl azodicarboxylate; potassium carbonate; ozone; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; acetyl chloride; triphenylphosphine; lithium chloride; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; 5.1: Swern oxidation / 6.1: Grignard reaction / 9.1: Mitsunobu reaction;
DOI:10.1081/SCC-120022181