1-(1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(piperidin-1-yl)ethanone

Base Information

• Chemical Name: 1-(1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(piperidin-1-yl)ethanone
• CAS No.: 670270-31-2
• Molecular Formula: C₁₉H₂₃ClN₂O
• Molecular Weight: 330.857

Synonyms:1-(1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(piperidin-1-yl)ethanone

Chemical Property of 1-(1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(piperidin-1-yl)ethanone

Chemical Property:

• Boiling Point: 475.1±45.0 °C(Predicted)
• Density: 1.18±0.1 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

IU1-47 ≥98%(HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 1-(1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(piperidin-1-yl)ethanone

There total 3 articles about 1-(1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(piperidin-1-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.8%

piperidine (110-89-4) + 2-chloro-1-(1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)ethanone (571159-05-2) → 1-(1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(piperidin-1-yl)ethanone (670270-31-2)

Guidance literature:

With triethylamine; In acetonitrile; for 1h; Reflux;

Reference yield:

2,5-hexanedione (110-13-4) → 1-(1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(piperidin-1-yl)ethanone (670270-31-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: acetic acid / 1 h / 100 °C

2.1: aluminum (III) chloride / 1,2-dichloro-ethane / 0.5 h / 0 °C

2.2: 2 h / 0 - 20 °C

3.1: triethylamine / acetonitrile / 1 h / Reflux

With aluminum (III) chloride; acetic acid; triethylamine; In 1,2-dichloro-ethane; acetonitrile;

Reference yield:

4-chloro-aniline (106-47-8) → 1-(1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(piperidin-1-yl)ethanone (670270-31-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: acetic acid / 1 h / 100 °C

2.1: aluminum (III) chloride / 1,2-dichloro-ethane / 0.5 h / 0 °C

2.2: 2 h / 0 - 20 °C

3.1: triethylamine / acetonitrile / 1 h / Reflux

With aluminum (III) chloride; acetic acid; triethylamine; In 1,2-dichloro-ethane; acetonitrile;

upstream raw materials:

2,5-hexanedione

piperidine

2-chloro-1-(1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)ethanone

4-chloro-aniline

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