(+)-pinanediol N-(2-pyrazinecarbonyl)-L-tyrosine-L-phenylalanine-L-leucineboronate

Base Information

• Chemical Name: (+)-pinanediol N-(2-pyrazinecarbonyl)-L-tyrosine-L-phenylalanine-L-leucineboronate
• CAS No.: 1194235-31-8
• Molecular Formula: C₃₈H₄₈BN₅O₆
• Molecular Weight: 681.64
• Mol file: 1194235-31-8.mol

Synonyms:(+)-pinanediol N-(2-pyrazinecarbonyl)-L-tyrosine-L-phenylalanine-L-leucineboronate

Chemical Property of (+)-pinanediol N-(2-pyrazinecarbonyl)-L-tyrosine-L-phenylalanine-L-leucineboronate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of (+)-pinanediol N-(2-pyrazinecarbonyl)-L-tyrosine-L-phenylalanine-L-leucineboronate

There total 1 articles about (+)-pinanediol N-(2-pyrazinecarbonyl)-L-tyrosine-L-phenylalanine-L-leucineboronate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

N-(2-pyrazinecarbonyl)-L-tyrosine-L-phenylalanine (1194235-17-0) + (1R)-3-methyl-1-[(3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methano-1,3,2-benzodioxabor-ol-2-yl]butan-1-amine hydrochloride (779357-85-6) → (+)-pinanediol N-(2-pyrazinecarbonyl)-L-tyrosine-L-phenylalanine-L-leucineboronate (1194235-31-8)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -20 - 20 ℃;

DOI:10.1016/j.bmc.2009.08.023

Reference yield: 71.5%

(+)-pinanediol N-(2-pyrazinecarbonyl)-L-tyrosine-L-phenylalanine-L-leucineboronate (1194235-31-8) → N-(2-pyrazinecarbonyl)-L-tyrosine-L-phenylalanine-L-leucineboronic acid (1194235-44-3)

Guidance literature:

With boron tribromide; In dichloromethane; at 0 ℃; for 2h;

DOI:10.1016/j.bmc.2009.08.023

upstream raw materials:

N-(2-pyrazinecarbonyl)-L-tyrosine-L-phenylalanine

(1R)-3-methyl-1-[(3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methano-1,3,2-benzodioxabor-ol-2-yl]butan-1-amine hydrochloride

Downstream raw materials:

N-(2-pyrazinecarbonyl)-L-tyrosine-L-phenylalanine-L-leucineboronic acid