Acetic acid 1-acetoxymethyl-2-(4-chloro-phenoxy)-ethyl ester

Base Information

• Chemical Name: Acetic acid 1-acetoxymethyl-2-(4-chloro-phenoxy)-ethyl ester
• CAS No.: 911835-63-7
• Molecular Formula: C₁₃H₁₅ClO₅
• Molecular Weight: 286.712
• Mol file: 911835-63-7.mol

Synonyms:Acetic acid 1-acetoxymethyl-2-(4-chloro-phenoxy)-ethyl ester

Chemical Property of Acetic acid 1-acetoxymethyl-2-(4-chloro-phenoxy)-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of Acetic acid 1-acetoxymethyl-2-(4-chloro-phenoxy)-ethyl ester

There total 2 articles about Acetic acid 1-acetoxymethyl-2-(4-chloro-phenoxy)-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-chlorophenyl 2,3-epoxypropyl ether (2212-05-7) + acetic anhydride (108-24-7) → Acetic acid 1-acetoxymethyl-2-(4-chloro-phenoxy)-ethyl ester (911835-63-7)

Guidance literature:

With ammonium molybdophosphate; at 20 ℃; for 1h;

DOI:10.1016/j.tetlet.2006.07.055

Reference yield:

vinyl acetate (108-05-4,9003-20-7) + chlorphenesin (104-29-0) → (S)-1-acetoxy-3-(4-chlorophenoxy)propan-2-ol (147220-31-3) + (R)-1-acetoxy-3-(4-chlorophenoxy)propan-2-ol (147220-31-3) + Acetic acid 1-acetoxymethyl-2-(4-chloro-phenoxy)-ethyl ester (911835-63-7)

Guidance literature:

With triethylamine; In tetrahydrofuran; for 25h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; lipase amano PS;

DOI:10.1021/jo00081a018

Reference yield:

Acetic acid 1-acetoxymethyl-2-(4-chloro-phenoxy)-ethyl ester (911835-63-7) → (R)-3-(4-chlorophenoxy)propane-1,2-diol (112652-61-6) + (S)-3-(4-chlorophenoxy)propane-1,2-diol

Guidance literature:

With ion-exchange resin Wofatit SBW (OH(-)-form); In methanol; Title compound not separated from byproducts;

DOI:10.1021/jo00081a018

upstream raw materials:

vinyl acetate

chlorphenesin

4-chlorophenyl 2,3-epoxypropyl ether

acetic anhydride

Downstream raw materials:

(R)-3-(4-chlorophenoxy)propane-1,2-diol