3,4-dihydroxyphenyl-2-methyl-L-alanine (1,3-dihydro-2H-benzimidazol-2-one-1-yl)piperidinamide hydrochloride

Base Information

Chemical Name:3,4-dihydroxyphenyl-2-methyl-L-alanine (1,3-dihydro-2H-benzimidazol-2-one-1-yl)piperidinamide hydrochloride
CAS No.:78734-34-6
Molecular Formula:C₂₂H₂₆N₄O₄*ClH
Molecular Weight:446.934
Hs Code.:

Synonyms:3,4-dihydroxyphenyl-2-methyl-L-alanine (1,3-dihydro-2H-benzimidazol-2-one-1-yl)piperidinamide hydrochloride

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Chemical Property of 3,4-dihydroxyphenyl-2-methyl-L-alanine (1,3-dihydro-2H-benzimidazol-2-one-1-yl)piperidinamide hydrochloride

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Technology Process of 3,4-dihydroxyphenyl-2-methyl-L-alanine (1,3-dihydro-2H-benzimidazol-2-one-1-yl)piperidinamide hydrochloride

There total 3 articles about 3,4-dihydroxyphenyl-2-methyl-L-alanine (1,3-dihydro-2H-benzimidazol-2-one-1-yl)piperidinamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.3%

: 78734-33-5
N-benzyloxycarbonyl-3,4-dibenzyloxycarbonyloxyphenyl-2-methyl-L-alanine<4-(1,3-dihydro-2H-benzimidazol-2-one-1-yl)>piperidinamide

: 78734-34-6
3,4-dihydroxyphenyl-2-methyl-L-alanine (1,3-dihydro-2H-benzimidazol-2-one-1-yl)piperidinamide hydrochloride

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; for 3h; Ambient temperature;
DOI:10.1248/cpb.30.474

Reference yield:

: 555-30-6,555-29-3,88620-56-8
3-(3,4-Dihydroxyphenyl)-2-methyl-L-alanine

: 78734-34-6
3,4-dihydroxyphenyl-2-methyl-L-alanine (1,3-dihydro-2H-benzimidazol-2-one-1-yl)piperidinamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 36.3 percent / NaOH / H₂O; diethyl ether / 3 h / 0 °C

2: 62.1 percent / DCC / CH₂Cl₂ / 5 h / 0 °C

3: 48.3 percent / H₂, HCl / Pd/C / methanol / 3 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; diethyl ether; dichloromethane; water;
DOI:10.1248/cpb.30.474

Reference yield:

: 61406-62-0
N,O,O'-tribenzyloxycarbonyl-methyldopa

: 78734-34-6
3,4-dihydroxyphenyl-2-methyl-L-alanine (1,3-dihydro-2H-benzimidazol-2-one-1-yl)piperidinamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 62.1 percent / DCC / CH₂Cl₂ / 5 h / 0 °C

2: 48.3 percent / H₂, HCl / Pd/C / methanol / 3 h / Ambient temperature

With hydrogenchloride; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1248/cpb.30.474