phosphoric acid 2-(4-{4-[2-(1-acetyl-5-methyl-7-nitro-2,3-dihydro-1H-indol-4-yloxy)-ethoxy]-benzoyl}-phenoxy)-ethyl ester di-tert-butyl ester

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Chemical Name:phosphoric acid 2-(4-{4-[2-(1-acetyl-5-methyl-7-nitro-2,3-dihydro-1H-indol-4-yloxy)-ethoxy]-benzoyl}-phenoxy)-ethyl ester di-tert-butyl ester
CAS No.:835889-78-6
Molecular Formula:C₃₆H₄₅N₂O₁₁P
Molecular Weight:712.734
Hs Code.:

phosphoric acid 2-(4-{4-[2-(1-acetyl-5-methyl-7-nitro-2,3-dihydro-1<i>H</i>-indol-4-yloxy)-ethoxy]-benzoyl}-phenoxy)-ethyl ester di-<i>tert</i>-butyl ester

Synonyms:phosphoric acid 2-(4-{4-[2-(1-acetyl-5-methyl-7-nitro-2,3-dihydro-1H-indol-4-yloxy)-ethoxy]-benzoyl}-phenoxy)-ethyl ester di-tert-butyl ester

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Chemical Property of phosphoric acid 2-(4-{4-[2-(1-acetyl-5-methyl-7-nitro-2,3-dihydro-1H-indol-4-yloxy)-ethoxy]-benzoyl}-phenoxy)-ethyl ester di-tert-butyl ester

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Technology Process of phosphoric acid 2-(4-{4-[2-(1-acetyl-5-methyl-7-nitro-2,3-dihydro-1H-indol-4-yloxy)-ethoxy]-benzoyl}-phenoxy)-ethyl ester di-tert-butyl ester

There total 15 articles about phosphoric acid 2-(4-{4-[2-(1-acetyl-5-methyl-7-nitro-2,3-dihydro-1H-indol-4-yloxy)-ethoxy]-benzoyl}-phenoxy)-ethyl ester di-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 835889-70-8
1-acetyl-4-(2-hydroxyethoxy)-5-methyl-7-nitroindoline

: 835889-71-9
4-{2-[di(tert-butoxy)phosphoryloxy]ethoxy}-4'-hydroxybenzophenone

: 835889-78-6
phosphoric acid 2-(4-{4-[2-(1-acetyl-5-methyl-7-nitro-2,3-dihydro-1H-indol-4-yloxy)-ethoxy]-benzoyl}-phenoxy)-ethyl ester di-tert-butyl ester

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 24h;
DOI:10.1016/j.tet.2004.10.094

Reference yield:

: 19499-82-2
5-(N,N-dimethylaminomethyl)indol-4-ol

: 835889-78-6
phosphoric acid 2-(4-{4-[2-(1-acetyl-5-methyl-7-nitro-2,3-dihydro-1H-indol-4-yloxy)-ethoxy]-benzoyl}-phenoxy)-ethyl ester di-tert-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 87 percent / H₂ / Pd-alumina / ethanol / 3800 Torr

2: NaBH₃CN; AcOH / 1 h / 15 °C

3: 73 percent / AcOH / 1 h / Heating

4: 80 percent / aq. NaOH / methanol / 0.75 h / 20 °C

5: 74 percent / Et₄NBr / dimethylformamide / 20 h / 140 °C

6: 95 percent / imidazole / CH₂Cl₂ / 20 °C

7: 86 percent / claycop; Ac₂O / CCl₄ / 3 h / 20 °C

8: 84 percent / TBAF; HOAc / tetrahydrofuran / 20 °C

9: 88 percent / Ph₃P; diisopropyl azodicarboxylate / tetrahydrofuran / 24 h / 20 °C

With 1H-imidazole; sodium hydroxide; di-isopropyl azodicarboxylate; tetraethylammonium bromide; tetrabutyl ammonium fluoride; hydrogen; acetic anhydride; sodium cyanoborohydride; copper(II) nitrate; acetic acid; triphenylphosphine; palladium matal-containing silica-supported catalyst; In tetrahydrofuran; methanol; tetrachloromethane; ethanol; dichloromethane; N,N-dimethyl-formamide; 9: Mitsunobu coupling;
DOI:10.1016/j.tet.2004.10.094

Reference yield:

: 770250-79-8
1-acetyl-5-methylindolin-4-ol

: 835889-78-6
phosphoric acid 2-(4-{4-[2-(1-acetyl-5-methyl-7-nitro-2,3-dihydro-1H-indol-4-yloxy)-ethoxy]-benzoyl}-phenoxy)-ethyl ester di-tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 74 percent / Et₄NBr / dimethylformamide / 20 h / 140 °C

2: 95 percent / imidazole / CH₂Cl₂ / 20 °C

3: 86 percent / claycop; Ac₂O / CCl₄ / 3 h / 20 °C

4: 84 percent / TBAF; HOAc / tetrahydrofuran / 20 °C

5: 88 percent / Ph₃P; diisopropyl azodicarboxylate / tetrahydrofuran / 24 h / 20 °C

With 1H-imidazole; di-isopropyl azodicarboxylate; tetraethylammonium bromide; tetrabutyl ammonium fluoride; acetic anhydride; copper(II) nitrate; acetic acid; triphenylphosphine; In tetrahydrofuran; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; 5: Mitsunobu coupling;
DOI:10.1016/j.tet.2004.10.094