4-amino-7-(2,3,5-tri-O-benzyl-β-D-arabinofuranosyl)pyrrolo<2,3-d>pyrimidine-5-carboxamide

Base Information

Chemical Name:4-amino-7-(2,3,5-tri-O-benzyl-β-D-arabinofuranosyl)pyrrolo<2,3-d>pyrimidine-5-carboxamide
CAS No.:110089-56-0
Molecular Formula:C₃₃H₃₃N₅O₅
Molecular Weight:579.656
Hs Code.:

Synonyms:4-amino-7-(2,3,5-tri-O-benzyl-β-D-arabinofuranosyl)pyrrolo<2,3-d>pyrimidine-5-carboxamide

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Chemical Property of 4-amino-7-(2,3,5-tri-O-benzyl-β-D-arabinofuranosyl)pyrrolo<2,3-d>pyrimidine-5-carboxamide

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Technology Process of 4-amino-7-(2,3,5-tri-O-benzyl-β-D-arabinofuranosyl)pyrrolo<2,3-d>pyrimidine-5-carboxamide

There total 6 articles about 4-amino-7-(2,3,5-tri-O-benzyl-β-D-arabinofuranosyl)pyrrolo<2,3-d>pyrimidine-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 110089-55-9
4-amino-7-(2,3,5-tri-O-benzyl-β-D-arabinofuranosyl)pyrrolo<2,3-d>pyrimidine-5-carbonitrile

: 110089-56-0
4-amino-7-(2,3,5-tri-O-benzyl-β-D-arabinofuranosyl)pyrrolo<2,3-d>pyrimidine-5-carboxamide

Guidance literature:: With ammonium hydroxide; dihydrogen peroxide; In 1,4-dioxane; methanol; water; for 12h; Ambient temperature;
DOI:10.1016/S0040-4020(01)96068-5

Reference yield:

: 98130-58-6
2-amino-5-bromo-1H-pyrrole-3,4-dicarbonitrile

: 110089-56-0
4-amino-7-(2,3,5-tri-O-benzyl-β-D-arabinofuranosyl)pyrrolo<2,3-d>pyrimidine-5-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / acetonitrile / 3 h / Heating

2: 74.5 percent / NaH / acetonitrile

3: 76.5 percent / NH₃ / methanol / 48 h / Ambient temperature

4: 97 percent / pyridine / 4 h / Ambient temperature

5: 57 percent / KF, N,O-bis(trimethylsilyl)acetamide / 18-crown-6 ether / acetonitrile / 12 h / Heating

6: 80 percent / NH₄OH, H₂O₂ / dioxane; methanol; H₂O / 12 h / Ambient temperature

With potassium fluoride; ammonium hydroxide; N,O-bis-(trimethylsilyl)-acetamide; ammonia; dihydrogen peroxide; sodium hydride; 18-crown-6 ether; In 1,4-dioxane; pyridine; methanol; water; acetonitrile;
DOI:10.1016/S0040-4020(01)96068-5

Reference yield:

: 110089-43-5
2-bromo-5-(ethoxymethyleneamino)pyrrole-3,4-dicarbonitrile

: 110089-56-0
4-amino-7-(2,3,5-tri-O-benzyl-β-D-arabinofuranosyl)pyrrolo<2,3-d>pyrimidine-5-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: 74.5 percent / NaH / acetonitrile

2: 76.5 percent / NH₃ / methanol / 48 h / Ambient temperature

3: 97 percent / pyridine / 4 h / Ambient temperature

4: 57 percent / KF, N,O-bis(trimethylsilyl)acetamide / 18-crown-6 ether / acetonitrile / 12 h / Heating

5: 80 percent / NH₄OH, H₂O₂ / dioxane; methanol; H₂O / 12 h / Ambient temperature

With potassium fluoride; ammonium hydroxide; N,O-bis-(trimethylsilyl)-acetamide; ammonia; dihydrogen peroxide; sodium hydride; 18-crown-6 ether; In 1,4-dioxane; pyridine; methanol; water; acetonitrile;
DOI:10.1016/S0040-4020(01)96068-5