ethyl 6-chloro-5-[1-hydroxy-2-(methoxycarbonyl)allyl]-2-phenylnicotinate

Base Information

Chemical Name:ethyl 6-chloro-5-[1-hydroxy-2-(methoxycarbonyl)allyl]-2-phenylnicotinate
CAS No.:899800-30-7
Molecular Formula:C₁₉H₁₈ClNO₅
Molecular Weight:375.809
Hs Code.:

Synonyms:ethyl 6-chloro-5-[1-hydroxy-2-(methoxycarbonyl)allyl]-2-phenylnicotinate

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Chemical Property of ethyl 6-chloro-5-[1-hydroxy-2-(methoxycarbonyl)allyl]-2-phenylnicotinate

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Technology Process of ethyl 6-chloro-5-[1-hydroxy-2-(methoxycarbonyl)allyl]-2-phenylnicotinate

There total 1 articles about ethyl 6-chloro-5-[1-hydroxy-2-(methoxycarbonyl)allyl]-2-phenylnicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 876345-32-3
2-chloro-5-(ethoxycarbonyl)-6-phenylnicotinaldehyde

: 140-88-5,9003-32-1
ethyl acrylate

: 899800-30-7
ethyl 6-chloro-5-[1-hydroxy-2-(methoxycarbonyl)allyl]-2-phenylnicotinate

Guidance literature:: 1,4-diaza-bicyclo[2.2.2]octane; at 20 ℃; for 0.0833333h; Product distribution / selectivity; Neat (no solvent);

Reference yield:

: 899800-30-7
ethyl 6-chloro-5-[1-hydroxy-2-(methoxycarbonyl)allyl]-2-phenylnicotinate

: 108-24-7
acetic anhydride

: 899800-03-4
5-(1-acetoxy-2-methoxycarbonyl-allyl)-6-chloro-2-phenyl-nicotinic acid ethyl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 - 5 ℃;
DOI:10.1016/j.bmc.2006.02.020

Reference yield:

: 899800-30-7
ethyl 6-chloro-5-[1-hydroxy-2-(methoxycarbonyl)allyl]-2-phenylnicotinate

: 3-ethyl 6-methyl 2-phenyl-8-methyl-3,6-quinolinedicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 0 - 5 °C

2: potassium carbonate / dimethylformamide / 20 °C

3: potassium carbonate / dimethylformamide / 2 h / 50 °C

With dmap; potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.02.020