2-(4-tert-butyl-1-hydroxy-cyclohexyl)-propionic acid ethyl ester

Base Information

• Chemical Name: 2-(4-tert-butyl-1-hydroxy-cyclohexyl)-propionic acid ethyl ester
• CAS No.: 1026807-63-5
• Molecular Formula: C₁₅H₂₈O₃
• Molecular Weight: 256.386
• Mol file: 1026807-63-5.mol

Synonyms:2-(4-tert-butyl-1-hydroxy-cyclohexyl)-propionic acid ethyl ester

Chemical Property of 2-(4-tert-butyl-1-hydroxy-cyclohexyl)-propionic acid ethyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-(4-tert-butyl-1-hydroxy-cyclohexyl)-propionic acid ethyl ester

There total 1 articles about 2-(4-tert-butyl-1-hydroxy-cyclohexyl)-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-tercbutyl-cyclohexanone (98-53-3) + Ethyl 2-bromopropionate (535-11-5,41978-69-2) → 2-(4-tert-butyl-1-hydroxy-cyclohexyl)-propionic acid ethyl ester (1026807-63-5)

Guidance literature:

With iodine; zinc; In benzene; for 2.5h; Heating;

DOI:10.1021/jo011178m

Reference yield: 66.0%

2-(4-tert-butyl-1-hydroxy-cyclohexyl)-propionic acid ethyl ester (1026807-63-5) → 2-(4-tert-butyl-cyclohex-1-enyl)-propionic acid (225792-72-3) + 2-(4-tert-butyl-cyclohexylidene)-propionic acid ethyl ester (503003-76-7)

Guidance literature:

2-(4-tert-butyl-1-hydroxy-cyclohexyl)-propionic acid ethyl ester; With pyridine; thionyl chloride; In diethyl ether; at 20 ℃; for 48h;

With sodium hydroxide; In ethanol; water; at 30 ℃; for 0.333333h; Further stages.;

DOI:10.1021/jo011178m

Reference yield:

2-(4-tert-butyl-1-hydroxy-cyclohexyl)-propionic acid ethyl ester (1026807-63-5) → 2-(4-tert-butyl-cyclohex-1-enyl)-propan-1-ol (433978-60-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: SOCl₂; pyridine / diethyl ether / 48 h / 20 °C

1.2: 66 percent / NaOH / H₂O; ethanol / 0.33 h / 30 °C

2.1: 95 percent / LiAlH₄ / tetrahydrofuran / 5 h / 20 °C

With pyridine; lithium aluminium tetrahydride; thionyl chloride; In tetrahydrofuran; diethyl ether;

DOI:10.1021/jo011178m

upstream raw materials:

4-tercbutyl-cyclohexanone

Ethyl 2-bromopropionate

Downstream raw materials:

2-(4-tert-butyl-cyclohex-1-enyl)-propionic acid

2-(4-tert-butyl-cyclohexylidene)-propionic acid ethyl ester

2-(4-tert-butyl-cyclohex-1-enyl)-propan-1-ol